3-Oxazolidinecarboxylic acid, 4-[[[1-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl] -2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]carbonyl]-2,2-dimeth yl-, phenylmethyl ester, (4S)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 4-[[[1-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl] -2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]carbonyl]-2,2-dimeth yl-, phenylmethyl ester, (4S)-
CAS No.:666215-53-8
Molecular Formula:C36H50N4O9SSi
Molecular Weight:742.966
Hs Code.:

3-Oxazolidinecarboxylic acid,
4-[[[1-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl]
-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]carbonyl]-2,2-dimeth
yl-, phenylmethyl ester, (4S)-

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Chemical Property of 3-Oxazolidinecarboxylic acid, 4-[[[1-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl] -2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]carbonyl]-2,2-dimeth yl-, phenylmethyl ester, (4S)-

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Technology Process of 3-Oxazolidinecarboxylic acid, 4-[[[1-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl] -2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]carbonyl]-2,2-dimeth yl-, phenylmethyl ester, (4S)-

There total 6 articles about 3-Oxazolidinecarboxylic acid, 4-[[[1-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl] -2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]carbonyl]-2,2-dimeth yl-, phenylmethyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 161891-81-2
(S)-3-((benzyloxy)carbonyl)-2,2-dimethyloxazolidine-4-carboxylic acid

: 666215-52-7
2-{2-[1-azido-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-dimethoxymethyl-pyridin-3-yl}-thiazole-4-carboxylic acid ethyl ester

: 666215-53-8
4-{2-(tert-butyl-dimethyl-silanyloxy)-1-[6-dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-ethylcarbamoyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: 2-{2-[1-azido-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-dimethoxymethyl-pyridin-3-yl}-thiazole-4-carboxylic acid ethyl ester; With hydrogen; palladium on activated charcoal; In methanol;

(S)-3-((benzyloxy)carbonyl)-2,2-dimethyloxazolidine-4-carboxylic acid; With diphenyl phosphoryl azide; triethylamine;
DOI:10.3987/COM-03-S27

Reference yield:

: 214040-92-3
2-(6-Dimethoxymethyl-2-trifluoromethanesulfonyloxy-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester

: 666215-53-8
4-{2-(tert-butyl-dimethyl-silanyloxy)-1-[6-dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-ethylcarbamoyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 96 percent / LiCl; Pd(PPh₃)4 / tetrahydrofuran

2.1: 90 percent / OsO₄; N-methylmorpholine N-oxide / CHCl₃

3.1: Et₃N

4.1: Et₃N

5.1: NaN₃ / dimethylformamide

6.1: H₂ / 10 percent Pd-C / methanol

6.2: 89 percent / diphenyl phosphorazidate; Et₃N

With osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; hydrogen; 4-methylmorpholine N-oxide; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.3987/COM-03-S27

Reference yield:

: 666215-49-2
2-(6-dimethoxymethyl-2-vinyl-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester

: 666215-53-8
4-{2-(tert-butyl-dimethyl-silanyloxy)-1-[6-dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-ethylcarbamoyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / OsO₄; N-methylmorpholine N-oxide / CHCl₃

2.1: Et₃N

3.1: Et₃N

4.1: NaN₃ / dimethylformamide

5.1: H₂ / 10 percent Pd-C / methanol

5.2: 89 percent / diphenyl phosphorazidate; Et₃N

With osmium(VIII) oxide; sodium azide; hydrogen; 4-methylmorpholine N-oxide; triethylamine; palladium on activated charcoal; In methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.3987/COM-03-S27