161891-81-2

Usage

Uses

Used in Pharmaceutical Industry:
(R)-3-((Benzyloxy)carbonyl)-2,2-dimethyloxazolidine-4-carboxylic acid is used as a building block for the synthesis of new bioactive molecules due to its versatile functional groups and chiral configuration.
Used in Antimicrobial Applications:
As a derivative of oxazolidinone antibiotics, (R)-3-((Benzyloxy)carbonyl)-2,2-dimethyloxazolidine-4-carboxylic acid is used as a potential antimicrobial agent for the development of new antibiotics, targeting various bacterial infections.
Used in Research and Development:
(R)-3-((BENZYLOXY)CARBONYL)-2,2-DIMETHYLOXAZOLIDINE-4-CARBOXYLIC ACID serves as a subject of interest for further research and development in the pharmaceutical industry, given its potential applications in creating novel bioactive molecules and antibiotics.

Upstream product

• 501-53-1 benzyl chloroformate 
• 1676-81-9 N-benzyloxycarbonyl-L-serine methyl ester 
• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 1569294-33-2 C₂₅H₂₉ClN₂O₅ 
• 1168208-15-8 (S)-4-((E)-(R)-3-ethoxycarbonyl-1-hydroxymethyl-2-methyl-allylcarbamoyl)-2,2-dimethyloxazolidine-3-carboxylic acid benzyl ester 
• 334832-25-6 (S)-2-{[2-((S)-1-Benzyloxycarbonylamino-2-triethylsilanyloxy-ethyl)-5-methyl-oxazole-4-carbonyl]-amino}-3-(tert-butyl-diphenyl-silanyloxy)-propionic acid methyl ester 
• 334832-23-4 (S)-4-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methoxycarbonyl-ethylcarbamoyl]-5,2',2'-trimethyl-4',5'-dihydro-[2,4']bioxazolyl-3'-carboxylic acid benzyl ester 
• 334832-24-5 (S)-2-{[2-((S)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-5-methyl-oxazole-4-carbonyl]-amino}-3-(tert-butyl-diphenyl-silanyloxy)-propionic acid methyl ester 
• 334832-20-1 (S)-4-((1S,2R)-2-Hydroxy-1-methoxycarbonyl-propylcarbamoyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 334832-22-3 (S)-5,2',2'-Trimethyl-4',5'-dihydro-[2,4']bioxazolyl-4,3'-dicarboxylic acid 3'-benzyl ester 
• 334832-21-2 (S)-5,2',2'-Trimethyl-4',5'-dihydro-[2,4']bioxazolyl-4,3'-dicarboxylic acid 3'-benzyl ester 4-methyl ester 
• 666215-53-8 4-{2-(tert-butyl-dimethyl-silanyloxy)-1-[6-dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-ethylcarbamoyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 500354-62-1 2-[(S)-1-{(S)-2-[((S)-3-Benzyloxycarbonyl-2,2-dimethyl-oxazolidine-4-carbonyl)-amino]-3-hydroxy-3-methyl-butyrylamino}-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-methyl-oxazole-4-carboxylic acid methyl ester 
• 160821-20-5 (4S)-N-benzyloxycarbonyl-4-carbamoyl-2,2-dimethyl-1,3-oxazolidine 

Relevant academic research and scientific papers

Enantioselective organocatalytic conjugate reduction of β-AzoleContaining α,β-unsaturated aldehydes

β-Azole-contalnlng α,β-unsaturated aldehydes were successfully reduced under highly enantloselectlve organocatalytlc transfer hydrogenation conditions. The products were obtained In good yields and up to 94% optical purity. This simple process was success

Synthesis of the penta-oxazole core of telomestatin in a convergent approach to poly-oxazole macrocycles

The synthesis of the penta-oxazole core of telomestatin whose methyl derivative could be an advanced intermediate in its total synthesis by subsequent condensation with a suitably substituted oxazole was investigated. The biosynthesis of telomestatin was interpreted as a formal assembly of one cysteine, five serine, and two threonine sub-units. The successive use of amines bearing unprotected hydroxymethyl groups permitted iterative assembly of polyoxazoles without the need for repeated protection and deprotection. It also permitted regioselective introduction of substituents at the 5-position of one or more oxazole rings and a variety of analogues to probe telomerase function. The synthetic route also provided several linked polyoxazole systems of increasing complexity and derived from serine as the only amino acid.

Useful synthesis of the main dehydrohexapeptide segment of a macrocyclic antibiotic, berninamycin B

The useful synthesis of tetradehydrohexapeptide segment 2, which is the main skeleton of a macrocyclic antibiotic, berninamycin B, was first achieved. The skeleton 2 is constructed, in turn, of 2-[(Z)-1-amino-1-propenyl]-5-methyl-oxazole-4-carboxylic acid, α-dehydroalanine (ΔAla), L-Val, 2-[1-amino-1-ethenyl]-5-methyloxazole-4-carboxylic acid residues, besides L-Thr and ΔAla at the N- and C-termini, respectively.

A Convenient Synthesis of Methyl 2-thazoline-4-carboxylate, an Important Skeleton of Cyclothiazomycin

The convenient syntheses of a few methyl 2-(1-amino)alkenyl thiazoline-4-carboxylates and methyl 2-thiazoline-4-carboxylate have been accomplished.The latter is an important portial skeleton of macrobicyclic peptide antibiotic cyclothiazomycin.