3-Oxazolidinecarboxylic acid, 4-[[[1-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl] -2-hydroxyethyl]amino]carbonyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 4-[[[1-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl] -2-hydroxyethyl]amino]carbonyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-
CAS No.:666215-54-9
Molecular Formula:C30H36N4O9S
Molecular Weight:628.703
Hs Code.:

3-Oxazolidinecarboxylic acid,
4-[[[1-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl]
-2-hydroxyethyl]amino]carbonyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-

Synonyms:

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Chemical Property of 3-Oxazolidinecarboxylic acid, 4-[[[1-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl] -2-hydroxyethyl]amino]carbonyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-

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Technology Process of 3-Oxazolidinecarboxylic acid, 4-[[[1-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl] -2-hydroxyethyl]amino]carbonyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-

There total 7 articles about 3-Oxazolidinecarboxylic acid, 4-[[[1-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl] -2-hydroxyethyl]amino]carbonyl]-2,2-dimethyl-, phenylmethyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 666215-53-8
4-{2-(tert-butyl-dimethyl-silanyloxy)-1-[6-dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-ethylcarbamoyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

: 666215-54-9
(S)-4-{1-[6-Dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-2-hydroxy-ethylcarbamoyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.3987/COM-03-S27

Reference yield:

: 214040-92-3
2-(6-Dimethoxymethyl-2-trifluoromethanesulfonyloxy-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester

: 666215-54-9
(S)-4-{1-[6-Dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-2-hydroxy-ethylcarbamoyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 96 percent / LiCl; Pd(PPh₃)4 / tetrahydrofuran

2.1: 90 percent / OsO₄; N-methylmorpholine N-oxide / CHCl₃

3.1: Et₃N

4.1: Et₃N

5.1: NaN₃ / dimethylformamide

6.1: H₂ / 10 percent Pd-C / methanol

6.2: 89 percent / diphenyl phosphorazidate; Et₃N

7.1: 87 percent / tetrabutylammonium fluoride / tetrahydrofuran

With osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; tetrabutyl ammonium fluoride; hydrogen; 4-methylmorpholine N-oxide; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.3987/COM-03-S27

Reference yield:

: 666215-49-2
2-(6-dimethoxymethyl-2-vinyl-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester

: 666215-54-9
(S)-4-{1-[6-Dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-2-hydroxy-ethylcarbamoyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 90 percent / OsO₄; N-methylmorpholine N-oxide / CHCl₃

2.1: Et₃N

3.1: Et₃N

4.1: NaN₃ / dimethylformamide

5.1: H₂ / 10 percent Pd-C / methanol

5.2: 89 percent / diphenyl phosphorazidate; Et₃N

6.1: 87 percent / tetrabutylammonium fluoride / tetrahydrofuran

With osmium(VIII) oxide; sodium azide; tetrabutyl ammonium fluoride; hydrogen; 4-methylmorpholine N-oxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.3987/COM-03-S27