3-Oxazolidinecarboxylic acid, 4-[4-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl]- 2-oxazolyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 4-[4-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl]- 2-oxazolyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-
CAS No.:666215-59-4
Molecular Formula:C₃₀H₃₂N₄O₈S
Molecular Weight:608.672
Hs Code.:

3-Oxazolidinecarboxylic acid,
4-[4-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl]-
2-oxazolyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-

Synonyms:

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Chemical Property of 3-Oxazolidinecarboxylic acid, 4-[4-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl]- 2-oxazolyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-

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Technology Process of 3-Oxazolidinecarboxylic acid, 4-[4-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl]- 2-oxazolyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-

There total 11 articles about 3-Oxazolidinecarboxylic acid, 4-[4-[6-(dimethoxymethyl)-3-[4-(ethoxycarbonyl)-2-thiazolyl]-2-pyridinyl]- 2-oxazolyl]-2,2-dimethyl-, phenylmethyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 67-56-1
methanol

: 666215-58-3
(S)-4-[3-(4-Ethoxycarbonyl-thiazol-2-yl)-6-formyl-pyridin-2-yl]-2',2'-dimethyl-4',5'-dihydro-[2,4']bioxazolyl-3'-carboxylic acid benzyl ester

: 666215-59-4
(S)-4-[6-Dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-2',2'-dimethyl-4',5'-dihydro-[2,4']bioxazolyl-3'-carboxylic acid benzyl ester

Guidance literature:: With toluene-4-sulfonic acid;
DOI:10.3987/COM-03-S27

Reference yield:

: 214040-92-3
2-(6-Dimethoxymethyl-2-trifluoromethanesulfonyloxy-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester

: 666215-59-4
(S)-4-[6-Dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-2',2'-dimethyl-4',5'-dihydro-[2,4']bioxazolyl-3'-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: 96 percent / LiCl; Pd(PPh₃)4 / tetrahydrofuran

2.1: 90 percent / OsO₄; N-methylmorpholine N-oxide / CHCl₃

3.1: Et₃N

4.1: Et₃N

5.1: NaN₃ / dimethylformamide

6.1: H₂ / 10 percent Pd-C / methanol

6.2: 89 percent / diphenyl phosphorazidate; Et₃N

7.1: 87 percent / tetrabutylammonium fluoride / tetrahydrofuran

8.1: Et₃N

8.2: 64 percent / DBU / CHCl₃

9.1: 71 percent / NBS

10.1: 65 percent / camphorsulfonic acid / toluene

11.1: 65 percent / p-toluenesulfonic acid

With N-Bromosuccinimide; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.3987/COM-03-S27

Reference yield:

: 666215-49-2
2-(6-dimethoxymethyl-2-vinyl-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester

: 666215-59-4
(S)-4-[6-Dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-2',2'-dimethyl-4',5'-dihydro-[2,4']bioxazolyl-3'-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: 90 percent / OsO₄; N-methylmorpholine N-oxide / CHCl₃

2.1: Et₃N

3.1: Et₃N

4.1: NaN₃ / dimethylformamide

5.1: H₂ / 10 percent Pd-C / methanol

5.2: 89 percent / diphenyl phosphorazidate; Et₃N

6.1: 87 percent / tetrabutylammonium fluoride / tetrahydrofuran

7.1: Et₃N

7.2: 64 percent / DBU / CHCl₃

8.1: 71 percent / NBS

9.1: 65 percent / camphorsulfonic acid / toluene

10.1: 65 percent / p-toluenesulfonic acid

With N-Bromosuccinimide; osmium(VIII) oxide; sodium azide; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.3987/COM-03-S27