4-Thiazolecarboxylic acid, 2-[6-(dimethoxymethyl)-2-[2-[(1S)-2-hydroxy-1-[[(phenylmethoxy)carbon yl]amino]ethyl]-4-oxazolyl]-3-pyridinyl]-, ethyl ester

Base Information

Chemical Name:4-Thiazolecarboxylic acid, 2-[6-(dimethoxymethyl)-2-[2-[(1S)-2-hydroxy-1-[[(phenylmethoxy)carbon yl]amino]ethyl]-4-oxazolyl]-3-pyridinyl]-, ethyl ester
CAS No.:666215-60-7
Molecular Formula:C27H28N4O8S
Molecular Weight:568.607
Hs Code.:

4-Thiazolecarboxylic acid,
2-[6-(dimethoxymethyl)-2-[2-[(1S)-2-hydroxy-1-[[(phenylmethoxy)carbon
yl]amino]ethyl]-4-oxazolyl]-3-pyridinyl]-, ethyl ester

Synonyms:

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Chemical Property of 4-Thiazolecarboxylic acid, 2-[6-(dimethoxymethyl)-2-[2-[(1S)-2-hydroxy-1-[[(phenylmethoxy)carbon yl]amino]ethyl]-4-oxazolyl]-3-pyridinyl]-, ethyl ester

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Technology Process of 4-Thiazolecarboxylic acid, 2-[6-(dimethoxymethyl)-2-[2-[(1S)-2-hydroxy-1-[[(phenylmethoxy)carbon yl]amino]ethyl]-4-oxazolyl]-3-pyridinyl]-, ethyl ester

There total 12 articles about 4-Thiazolecarboxylic acid, 2-[6-(dimethoxymethyl)-2-[2-[(1S)-2-hydroxy-1-[[(phenylmethoxy)carbon yl]amino]ethyl]-4-oxazolyl]-3-pyridinyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 666215-59-4
(S)-4-[6-Dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-2',2'-dimethyl-4',5'-dihydro-[2,4']bioxazolyl-3'-carboxylic acid benzyl ester

: 666215-60-7
2-{2-[2-((S)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-oxazol-4-yl]-6-dimethoxymethyl-pyridin-3-yl}-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: With acetic acid;
DOI:10.3987/COM-03-S27

Reference yield:

: 214040-92-3
2-(6-Dimethoxymethyl-2-trifluoromethanesulfonyloxy-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester

: 666215-60-7
2-{2-[2-((S)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-oxazol-4-yl]-6-dimethoxymethyl-pyridin-3-yl}-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: 96 percent / LiCl; Pd(PPh₃)4 / tetrahydrofuran

2.1: 90 percent / OsO₄; N-methylmorpholine N-oxide / CHCl₃

3.1: Et₃N

4.1: Et₃N

5.1: NaN₃ / dimethylformamide

6.1: H₂ / 10 percent Pd-C / methanol

6.2: 89 percent / diphenyl phosphorazidate; Et₃N

7.1: 87 percent / tetrabutylammonium fluoride / tetrahydrofuran

8.1: Et₃N

8.2: 64 percent / DBU / CHCl₃

9.1: 71 percent / NBS

10.1: 65 percent / camphorsulfonic acid / toluene

11.1: 65 percent / p-toluenesulfonic acid

12.1: 70 percent / 70 percent AcOH

With N-Bromosuccinimide; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; acetic acid; 4-methylmorpholine N-oxide; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.3987/COM-03-S27

Reference yield:

: 666215-49-2
2-(6-dimethoxymethyl-2-vinyl-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester

: 666215-60-7
2-{2-[2-((S)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-oxazol-4-yl]-6-dimethoxymethyl-pyridin-3-yl}-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: 90 percent / OsO₄; N-methylmorpholine N-oxide / CHCl₃

2.1: Et₃N

3.1: Et₃N

4.1: NaN₃ / dimethylformamide

5.1: H₂ / 10 percent Pd-C / methanol

5.2: 89 percent / diphenyl phosphorazidate; Et₃N

6.1: 87 percent / tetrabutylammonium fluoride / tetrahydrofuran

7.1: Et₃N

7.2: 64 percent / DBU / CHCl₃

8.1: 71 percent / NBS

9.1: 65 percent / camphorsulfonic acid / toluene

10.1: 65 percent / p-toluenesulfonic acid

11.1: 70 percent / 70 percent AcOH

With N-Bromosuccinimide; osmium(VIII) oxide; sodium azide; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; acetic acid; 4-methylmorpholine N-oxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.3987/COM-03-S27