4-Thiazolecarboxylic acid, 2-[6-(dimethoxymethyl)-2-[2-[(1S)-1-[[(phenylmethoxy)carbonyl]amino]-2 -[[tris(1-methylethyl)silyl]oxy]ethyl]-4-oxazolyl]-3-pyridinyl]-, ethyl ester

Base Information

Chemical Name:4-Thiazolecarboxylic acid, 2-[6-(dimethoxymethyl)-2-[2-[(1S)-1-[[(phenylmethoxy)carbonyl]amino]-2 -[[tris(1-methylethyl)silyl]oxy]ethyl]-4-oxazolyl]-3-pyridinyl]-, ethyl ester
CAS No.:666215-61-8
Molecular Formula:C36H48N4O8SSi
Molecular Weight:807.012
Hs Code.:

4-Thiazolecarboxylic acid,
2-[6-(dimethoxymethyl)-2-[2-[(1S)-1-[[(phenylmethoxy)carbonyl]amino]-2
-[[tris(1-methylethyl)silyl]oxy]ethyl]-4-oxazolyl]-3-pyridinyl]-, ethyl ester

Synonyms:

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Chemical Property of 4-Thiazolecarboxylic acid, 2-[6-(dimethoxymethyl)-2-[2-[(1S)-1-[[(phenylmethoxy)carbonyl]amino]-2 -[[tris(1-methylethyl)silyl]oxy]ethyl]-4-oxazolyl]-3-pyridinyl]-, ethyl ester

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Technology Process of 4-Thiazolecarboxylic acid, 2-[6-(dimethoxymethyl)-2-[2-[(1S)-1-[[(phenylmethoxy)carbonyl]amino]-2 -[[tris(1-methylethyl)silyl]oxy]ethyl]-4-oxazolyl]-3-pyridinyl]-, ethyl ester

There total 13 articles about 4-Thiazolecarboxylic acid, 2-[6-(dimethoxymethyl)-2-[2-[(1S)-1-[[(phenylmethoxy)carbonyl]amino]-2 -[[tris(1-methylethyl)silyl]oxy]ethyl]-4-oxazolyl]-3-pyridinyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 666215-60-7
2-{2-[2-((S)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-oxazol-4-yl]-6-dimethoxymethyl-pyridin-3-yl}-thiazole-4-carboxylic acid ethyl ester

: 666215-61-8
2-(2-{2-[1-benzyloxycarbonylamino-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-oxazol-4-yl}-6-dimethoxymethyl-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: With 1H-imidazole; In chloroform;
DOI:10.3987/COM-03-S27

Reference yield:

: 214040-92-3
2-(6-Dimethoxymethyl-2-trifluoromethanesulfonyloxy-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester

: 666215-61-8
2-(2-{2-[1-benzyloxycarbonylamino-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-oxazol-4-yl}-6-dimethoxymethyl-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 13 steps

1.1: 96 percent / LiCl; Pd(PPh₃)4 / tetrahydrofuran

2.1: 90 percent / OsO₄; N-methylmorpholine N-oxide / CHCl₃

3.1: Et₃N

4.1: Et₃N

5.1: NaN₃ / dimethylformamide

6.1: H₂ / 10 percent Pd-C / methanol

6.2: 89 percent / diphenyl phosphorazidate; Et₃N

7.1: 87 percent / tetrabutylammonium fluoride / tetrahydrofuran

8.1: Et₃N

8.2: 64 percent / DBU / CHCl₃

9.1: 71 percent / NBS

10.1: 65 percent / camphorsulfonic acid / toluene

11.1: 65 percent / p-toluenesulfonic acid

12.1: 70 percent / 70 percent AcOH

13.1: 85 percent / imidazole / CHCl₃

With 1H-imidazole; N-Bromosuccinimide; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; acetic acid; 4-methylmorpholine N-oxide; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.3987/COM-03-S27

Reference yield:

: 666215-49-2
2-(6-dimethoxymethyl-2-vinyl-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester

: 666215-61-8
2-(2-{2-[1-benzyloxycarbonylamino-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-oxazol-4-yl}-6-dimethoxymethyl-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: 90 percent / OsO₄; N-methylmorpholine N-oxide / CHCl₃

2.1: Et₃N

3.1: Et₃N

4.1: NaN₃ / dimethylformamide

5.1: H₂ / 10 percent Pd-C / methanol

5.2: 89 percent / diphenyl phosphorazidate; Et₃N

6.1: 87 percent / tetrabutylammonium fluoride / tetrahydrofuran

7.1: Et₃N

7.2: 64 percent / DBU / CHCl₃

8.1: 71 percent / NBS

9.1: 65 percent / camphorsulfonic acid / toluene

10.1: 65 percent / p-toluenesulfonic acid

11.1: 70 percent / 70 percent AcOH

12.1: 85 percent / imidazole / CHCl₃

With 1H-imidazole; N-Bromosuccinimide; osmium(VIII) oxide; sodium azide; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; acetic acid; 4-methylmorpholine N-oxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.3987/COM-03-S27