1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-7,11,15-trimethyl-13-methylene-2-(2,4,6-trimethylphenyl)-, (2R,5S,7R,10S,11E,15S,16E)-

Base Information

Chemical Name:1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-7,11,15-trimethyl-13-methylene-2-(2,4,6-trimethylphenyl)-, (2R,5S,7R,10S,11E,15S,16E)-
CAS No.:666715-16-8
Molecular Formula:C₃₀H₄₀O₅
Molecular Weight:480.645
Hs Code.:

1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione,
10-ethyl-7,11,15-trimethyl-13-methylene-2-(2,4,6-trimethylphenyl)-,
(2R,5S,7R,10S,11E,15S,16E)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-7,11,15-trimethyl-13-methylene-2-(2,4,6-trimethylphenyl)-, (2R,5S,7R,10S,11E,15S,16E)-

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Technology Process of 1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-7,11,15-trimethyl-13-methylene-2-(2,4,6-trimethylphenyl)-, (2R,5S,7R,10S,11E,15S,16E)-

There total 8 articles about 1,3,9-Trioxaspiro[4.13]octadeca-11,16-diene-6,8-dione, 10-ethyl-7,11,15-trimethyl-13-methylene-2-(2,4,6-trimethylphenyl)-, (2R,5S,7R,10S,11E,15S,16E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 241823-00-7
(E)-(2S,7S)-2,6-Dimethyl-4-methylene-7-(2-trimethylsilanyl-ethoxymethoxy)-non-5-enal

: 666715-16-8
(11E,16E)-(2R,5S,7R,10S,15S)-10-Ethyl-7,11,15-trimethyl-13-methylene-2-(2,4,6-trimethyl-phenyl)-1,3,9-trioxa-spiro[4.13]octadeca-11,16-diene-6,8-dione

Guidance literature:: Multi-step reaction with 9 steps

1.1: 80 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene; LiCl

2.1: 93 percent / diisobutylaluminum hydride

3.1: I₂; PPh₃; imidazole

4.1: LHMDS / hexamethylphosphoric acid triamide

5.1: tetraethylammonium fluoride

6.1: DMAP; pyridine

7.1: LHMDS / hexamethylphosphoric acid triamide

8.1: t-BuOK

8.2: t-BuOK

With pyridine; 1H-imidazole; dmap; potassium tert-butylate; iodine; diisobutylaluminium hydride; tetraethylammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; lithium chloride; lithium hexamethyldisilazane; In N,N,N,N,N,N-hexamethylphosphoric triamide; 1.1: Horner-Wadsworth-Emmons reaction / 8.1: Macro-Dieckmann cyclization;
DOI:10.1016/j.bmcl.2003.09.072

Reference yield:

: [2-((2E,7E)-(1S,6S)-1-Ethyl-9-iodo-2,6-dimethyl-4-methylene-nona-2,7-dienyloxymethoxy)-ethyl]-trimethyl-silane

: 666715-16-8
(11E,16E)-(2R,5S,7R,10S,15S)-10-Ethyl-7,11,15-trimethyl-13-methylene-2-(2,4,6-trimethyl-phenyl)-1,3,9-trioxa-spiro[4.13]octadeca-11,16-diene-6,8-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: LHMDS / hexamethylphosphoric acid triamide

2.1: tetraethylammonium fluoride

3.1: DMAP; pyridine

4.1: LHMDS / hexamethylphosphoric acid triamide

5.1: t-BuOK

5.2: t-BuOK

With pyridine; dmap; potassium tert-butylate; tetraethylammonium fluoride; lithium hexamethyldisilazane; In N,N,N,N,N,N-hexamethylphosphoric triamide; 5.1: Macro-Dieckmann cyclization;
DOI:10.1016/j.bmcl.2003.09.072

Reference yield:

: 594854-64-5
(2E,7E)-(4S,9S)-4,8-Dimethyl-6-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undeca-2,7-dien-1-ol

: 666715-16-8
(11E,16E)-(2R,5S,7R,10S,15S)-10-Ethyl-7,11,15-trimethyl-13-methylene-2-(2,4,6-trimethyl-phenyl)-1,3,9-trioxa-spiro[4.13]octadeca-11,16-diene-6,8-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: I₂; PPh₃; imidazole

2.1: LHMDS / hexamethylphosphoric acid triamide

3.1: tetraethylammonium fluoride

4.1: DMAP; pyridine

5.1: LHMDS / hexamethylphosphoric acid triamide

6.1: t-BuOK

6.2: t-BuOK

With pyridine; 1H-imidazole; dmap; potassium tert-butylate; iodine; tetraethylammonium fluoride; triphenylphosphine; lithium hexamethyldisilazane; In N,N,N,N,N,N-hexamethylphosphoric triamide; 6.1: Macro-Dieckmann cyclization;
DOI:10.1016/j.bmcl.2003.09.072