Acetamide, 2-[[2-[[(2,3-difluorophenyl)methyl]thio]-1,4-dihydro-6-[[(1R)-2-hydroxy-1- methylethyl]amino]-4-oxo-5-pyrimidinyl]thio]-N-[2-(dimethylamino)ethyl]-

Base Information

Chemical Name:Acetamide, 2-[[2-[[(2,3-difluorophenyl)methyl]thio]-1,4-dihydro-6-[[(1R)-2-hydroxy-1- methylethyl]amino]-4-oxo-5-pyrimidinyl]thio]-N-[2-(dimethylamino)ethyl]-
CAS No.:666752-83-6
Molecular Formula:C₂₀H₂₇F₂N₅O₃S₂
Molecular Weight:487.595
Hs Code.:

Acetamide,
2-[[2-[[(2,3-difluorophenyl)methyl]thio]-1,4-dihydro-6-[[(1R)-2-hydroxy-1-
methylethyl]amino]-4-oxo-5-pyrimidinyl]thio]-N-[2-(dimethylamino)ethyl]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetamide, 2-[[2-[[(2,3-difluorophenyl)methyl]thio]-1,4-dihydro-6-[[(1R)-2-hydroxy-1- methylethyl]amino]-4-oxo-5-pyrimidinyl]thio]-N-[2-(dimethylamino)ethyl]-

Chemical Property:

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Technology Process of Acetamide, 2-[[2-[[(2,3-difluorophenyl)methyl]thio]-1,4-dihydro-6-[[(1R)-2-hydroxy-1- methylethyl]amino]-4-oxo-5-pyrimidinyl]thio]-N-[2-(dimethylamino)ethyl]-

There total 3 articles about Acetamide, 2-[[2-[[(2,3-difluorophenyl)methyl]thio]-1,4-dihydro-6-[[(1R)-2-hydroxy-1- methylethyl]amino]-4-oxo-5-pyrimidinyl]thio]-N-[2-(dimethylamino)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 666752-81-4
ethyl [[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]acetate

: 108-00-9
N,N-dimethylethylenediamine

: 666752-83-6
2-[[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]-N-[2-(dimethylamino)ethyl]acetamide

Guidance literature:: In ethanol; for 48h;

Reference yield:

: 666752-67-6
2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-4-pyrimidinol

: 666752-83-6
2-[[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]-N-[2-(dimethylamino)ethyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; bromine / DMF (N,N-dimethyl-formamide) / 1 h

2: ethanol / 48 h

With pyridine; bromine; In DMF (N,N-dimethyl-formamide); ethanol;

Reference yield:

: 666752-51-8
6-{[(1R)-2-hydroxy-1-methylethyl]amino}-2-mercapto-4-pyrimidinol

: 666752-83-6
2-[[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]-N-[2-(dimethylamino)ethyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol; water / 1 h

2: pyridine; bromine / DMF (N,N-dimethyl-formamide) / 1 h

3: ethanol / 48 h

With pyridine; sodium hydroxide; bromine; In DMF (N,N-dimethyl-formamide); ethanol; water;