5-Pyrimidinecarboxaldehyde, 4-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]-1-methylethyl]amino]-

Base Information

Chemical Name:5-Pyrimidinecarboxaldehyde, 4-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]-1-methylethyl]amino]-
CAS No.:666752-91-6
Molecular Formula:C21H28ClF2N3O2SSi
Molecular Weight:488.074
Hs Code.:

5-Pyrimidinecarboxaldehyde,
4-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-[[(1,1-dimethyleth
yl)dimethylsilyl]oxy]-1-methylethyl]amino]-

Synonyms:

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Chemical Property of 5-Pyrimidinecarboxaldehyde, 4-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]-1-methylethyl]amino]-

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Technology Process of 5-Pyrimidinecarboxaldehyde, 4-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]-1-methylethyl]amino]-

There total 3 articles about 5-Pyrimidinecarboxaldehyde, 4-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]-1-methylethyl]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 666752-90-5
4-chloro-2-[(2,3-difluorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]-amino}-pyrimidine-5-carbaldehyde

: 18162-48-6
tert-butyldimethylsilyl chloride

: 666752-91-6
4-[((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)amino]-6-chloro-2-[(2,3-difluorobenzyl)thio]pyrimidine-5-carbaldehyde

Guidance literature:: With 1H-imidazole; In DMF (N,N-dimethyl-formamide); at -10 - 0 ℃; for 2h;

Reference yield:

: 666752-60-9
2-[(2,3-difluorobenzyl)thio]pyrimidine-4,6(1H,5H)-dione

: 666752-91-6
4-[((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)amino]-6-chloro-2-[(2,3-difluorobenzyl)thio]pyrimidine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 15 h / 5 - 100 °C

2: triethylamine / DMF (N,N-dimethyl-formamide) / 1 h / -5 - 20 °C

3: 1H-imidazole / DMF (N,N-dimethyl-formamide) / 2 h / -10 - 0 °C

With 1H-imidazole; triethylamine; trichlorophosphate; In DMF (N,N-dimethyl-formamide);

Reference yield:

: 113211-94-2
2,3-difluorobenzyl bromide

: 666752-91-6
4-[((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)amino]-6-chloro-2-[(2,3-difluorobenzyl)thio]pyrimidine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / ethanol; water / 22 h / 20 - 60 °C

2: trichlorophosphate / 15 h / 5 - 100 °C

3: triethylamine / DMF (N,N-dimethyl-formamide) / 1 h / -5 - 20 °C

4: 1H-imidazole / DMF (N,N-dimethyl-formamide) / 2 h / -10 - 0 °C

With 1H-imidazole; sodium hydroxide; triethylamine; trichlorophosphate; In DMF (N,N-dimethyl-formamide); ethanol; water;