4H-Pyrrolo[3,2-d]pyrimidin-4-one, 1,5-dihydro-5-[(phenylmethoxy)methyl]-7-[[(3R,4R)-3-(phenylmethoxy)-4 -[(phenylmethoxy)methyl]-1-pyrrolidinyl]methyl]-

Base Information

Chemical Name:4H-Pyrrolo[3,2-d]pyrimidin-4-one, 1,5-dihydro-5-[(phenylmethoxy)methyl]-7-[[(3R,4R)-3-(phenylmethoxy)-4 -[(phenylmethoxy)methyl]-1-pyrrolidinyl]methyl]-
CAS No.:666830-86-0
Molecular Formula:C34H36N4O4
Molecular Weight:564.684
Hs Code.:

4H-Pyrrolo[3,2-d]pyrimidin-4-one,
1,5-dihydro-5-[(phenylmethoxy)methyl]-7-[[(3R,4R)-3-(phenylmethoxy)-4
-[(phenylmethoxy)methyl]-1-pyrrolidinyl]methyl]-

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Chemical Property of 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 1,5-dihydro-5-[(phenylmethoxy)methyl]-7-[[(3R,4R)-3-(phenylmethoxy)-4 -[(phenylmethoxy)methyl]-1-pyrrolidinyl]methyl]-

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Technology Process of 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 1,5-dihydro-5-[(phenylmethoxy)methyl]-7-[[(3R,4R)-3-(phenylmethoxy)-4 -[(phenylmethoxy)methyl]-1-pyrrolidinyl]methyl]-

There total 7 articles about 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 1,5-dihydro-5-[(phenylmethoxy)methyl]-7-[[(3R,4R)-3-(phenylmethoxy)-4 -[(phenylmethoxy)methyl]-1-pyrrolidinyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 635319-15-2
7-(3-benzyloxy-4-benzyloxymethyl-pyrrolidin-1-ylmethyl)-5-benzyloxymethyl-4-tert-butoxy-5H-pyrrolo[3,2-d]pyrimidine

: 666830-86-0
7-[(3R,4R)-(3-benzyloxy-4-benzyloxymethylpyrrolidin-1-yl)methyl]-5-benzyloxymethyl-3H-pyrrolo[3,2-d]pyrimidin-4-one

Guidance literature:: With hydrogenchloride; In methanol; water; at 20 ℃; for 1h;

Reference yield: 63.0%

: 635319-15-2
7-(3-benzyloxy-4-benzyloxymethyl-pyrrolidin-1-ylmethyl)-5-benzyloxymethyl-4-tert-butoxy-5H-pyrrolo[3,2-d]pyrimidine

: 666830-86-0
(3R,4R)-1-[(7-benzyloxymethyl-9-deazahypoxanthin-9-yl)methyl]-3-benzyloxy-4-benzyloxymethylpyrrolidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm030305z

Reference yield:

: 299916-78-2
7-N-benzyloxymethyl-9-bromo-6-O-tert-butyl-9-deaza-hypoxanthine

: 666830-86-0
(3R,4R)-1-[(7-benzyloxymethyl-9-deazahypoxanthin-9-yl)methyl]-3-benzyloxy-4-benzyloxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / diethyl ether; methoxybenzene / 0.5 h / -78 °C

1.2: 78 percent / diethyl ether; methoxybenzene / 0.5 h / -78 °C

2.1: NaCNBH₃ / methanol / 20 °C

3.1: 63 percent / TFA / CH₂Cl₂ / 1 h / 20 °C

With n-butyllithium; sodium cyanoborohydride; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; methoxybenzene;
DOI:10.1021/jm030305z