(3R,4R)-tert-Butyl 3-Hydroxy-4-(hydroxyMethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(3R,4R)-tert-Butyl 3-Hydroxy-4-(hydroxyMethyl)pyrrolidine-1-carboxylate
CAS No.:635319-09-4
Molecular Formula:C10H19NO4
Molecular Weight:217.265
Hs Code.:
Mol file:635319-09-4.mol

Synonyms:N-tert-butoxycarbonyl-(3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine;tert-butyl trans(+-)-4-amino-3-hydroxypiperidine-1-carboxylate;tert-butyl (3R*,4R*)-4-amino-3-hydroxy-piperidine-1-carboxylate;(3R,4R)-1-tert-butoxycarbonyl-3-hydroxy-4-(hydroxymethyl)pyrrolidine;(3R,4R)-tert-butyl 3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate;(3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol;(3R,4R)-N-tert-butoxycarbonyl-3-hydroxy-4-hydroxymethylpyrrolidine;(3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidin-1-N-carboxylic acid tert-butyl ester;tert-butyl (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate;

Suppliers and Price of (3R,4R)-tert-Butyl 3-Hydroxy-4-(hydroxyMethyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3R,4R)-tert-Butyl3-Hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate
500mg
$ 1320.00

Medical Isotopes, Inc.
(3R,4R)-tert-Butyl3-Hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate
500 mg
$ 2200.00

Medical Isotopes, Inc.
(3R,4R)-tert-Butyl3-Hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate
50 mg
$ 650.00

J&W Pharmlab
(3R,4R)-1-Boc-3-hydroxy-4-(hydroxymethyl)-pyrrolidine 95%
250mg
$ 325.00

J&W Pharmlab
(3R,4R)-1-Boc-3-hydroxy-4-(hydroxymethyl)-pyrrolidine 95%
100mg
$ 212.00

J&W Pharmlab
(3R,4R)-1-Boc-3-hydroxy-4-(hydroxymethyl)-pyrrolidine 95%
50mg
$ 156.00

J&W Pharmlab
(3R,4R)-1-Boc-3-hydroxy-4-(hydroxymethyl)-pyrrolidine 95%
500mg
$ 549.00

J&W Pharmlab
(3R,4R)-1-Boc-3-hydroxy-4-(hydroxymethyl)-pyrrolidine 95%
5g
$ 3998.00

J&W Pharmlab
(3R,4R)-1-Boc-3-hydroxy-4-(hydroxymethyl)-pyrrolidine 95%
1g
$ 998.00

Crysdot
(3R,4R)-tert-Butyl3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate 95+%
5g
$ 2069.00

Total 17 raw suppliers

Chemical Property of (3R,4R)-tert-Butyl 3-Hydroxy-4-(hydroxyMethyl)pyrrolidine-1-carboxylate

Chemical Property:

Boiling Point:340.3±27.0 °C(Predicted)
PKA:14.49±0.40(Predicted)
PSA：70.00000
Density:1.190±0.06 g/cm3(Predicted)
LogP:0.14440
Storage Temp.:2-8°C

Purity/Quality:

≥99.0% ^*data from raw suppliers

(3R,4R)-tert-Butyl3-Hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (3R,4R)-tert-Butyl 3-Hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate has been used as a reactant for the preparation of transition state analogue inhibitors of human 5’-Methylthioadenosine phosphorylase (MTAP).

Technology Process of (3R,4R)-tert-Butyl 3-Hydroxy-4-(hydroxyMethyl)pyrrolidine-1-carboxylate

There total 16 articles about (3R,4R)-tert-Butyl 3-Hydroxy-4-(hydroxyMethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 253129-03-2
(3R, 4R)-1-benzyl-4-(hydroxymethyl)pyrrolidin-3-ol

: 24424-99-5
di-tert-butyl dicarbonate

: 635319-09-4
tert-butyl (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 24h;
DOI:10.1039/b517883e

Reference yield: 92.0%

: 635319-08-3
(3R,4S)-N-tert-butoxycarbonyl-4-[(1S)-1,2-dihydroxyethyl]-3-hydroxypyrrolidine

: 635319-09-4
tert-butyl (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: (3R,4S)-N-tert-butoxycarbonyl-4-[(1S)-1,2-dihydroxyethyl]-3-hydroxypyrrolidine; With sodium periodate; In ethanol; at 0 ℃; for 0.333333h;

With sodium tetrahydroborate; In ethanol; at 0 ℃;
DOI:10.1021/jm030305z