3-Pyrrolidinol, 1-[[7-methoxy-2-(tetrahydro-2H-pyran-2-yl)-2H-pyrazolo[4,3-d]pyrimidin- 3-yl]methyl]-4-[[(phenylmethyl)thio]methyl]-, (3R,4S)-

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Chemical Name:3-Pyrrolidinol, 1-[[7-methoxy-2-(tetrahydro-2H-pyran-2-yl)-2H-pyrazolo[4,3-d]pyrimidin- 3-yl]methyl]-4-[[(phenylmethyl)thio]methyl]-, (3R,4S)-
CAS No.:666831-27-2
Molecular Formula:C24H31N5O3S
Molecular Weight:469.608
Hs Code.:

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Chemical Property of 3-Pyrrolidinol, 1-[[7-methoxy-2-(tetrahydro-2H-pyran-2-yl)-2H-pyrazolo[4,3-d]pyrimidin- 3-yl]methyl]-4-[[(phenylmethyl)thio]methyl]-, (3R,4S)-

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Technology Process of 3-Pyrrolidinol, 1-[[7-methoxy-2-(tetrahydro-2H-pyran-2-yl)-2H-pyrazolo[4,3-d]pyrimidin- 3-yl]methyl]-4-[[(phenylmethyl)thio]methyl]-, (3R,4S)-

There total 4 articles about 3-Pyrrolidinol, 1-[[7-methoxy-2-(tetrahydro-2H-pyran-2-yl)-2H-pyrazolo[4,3-d]pyrimidin- 3-yl]methyl]-4-[[(phenylmethyl)thio]methyl]-, (3R,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 635319-14-1
8-aza-9-deaza-9-formyl-6-O-methyl-8-tetrahydropyranylhypoxanthine

: (3R,4S)-4-benzylthiomethyl-3-hydroxypyrrolidine hydrochloride

: 666831-27-2
(3R,4S)-1-{[8-aza-9-deaza-8-(tetrahydropyran-2-yl)-6-methoxyhypoxanthin-9-yl]methyl}-3-hydroxy-4-(benzylthiomethyl)pyrrolidine

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃;

Reference yield:

: 666831-24-9
tert-butyl (3R,4R)-3-hydroxy-4-[(methanesulfonyloxy)methyl]pyrrolidine-1-carboxylate

: 666831-27-2
(3R,4S)-1-{[8-aza-9-deaza-8-(tetrahydropyran-2-yl)-6-methoxyhypoxanthin-9-yl]methyl}-3-hydroxy-4-(benzylthiomethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide

1.2: dimethylformamide / 1 h / 20 °C

2.1: 730 mg / aq. HCl / methanol

3.1: sodium cyanoborohydride / methanol / 20 °C

With hydrogenchloride; sodium hydride; sodium cyanoborohydride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm050269z

Reference yield:

: 3R,4S-4-benzylthiomethyl-1-tert-butoxycarbonyl-3-hydroxypyrrolidine

: 666831-27-2
(3R,4S)-1-{[8-aza-9-deaza-8-(tetrahydropyran-2-yl)-6-methoxyhypoxanthin-9-yl]methyl}-3-hydroxy-4-(benzylthiomethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 730 mg / aq. HCl / methanol

2: sodium cyanoborohydride / methanol / 20 °C

With hydrogenchloride; sodium cyanoborohydride; In methanol;
DOI:10.1021/jm050269z