5-Iodo-2-(benzoylamino)pyrimidine-4(3H)-one

Base Information

• Chemical Name: 5-Iodo-2-(benzoylamino)pyrimidine-4(3H)-one
• CAS No.: 667411-75-8
• Molecular Formula: C11H8IN3O2
• Molecular Weight: 341.108
• DSSTox Substance ID: DTXSID20459258
• Nikkaji Number: J2.184.524H
• Wikidata: Q82282988
• Mol file: 667411-75-8.mol

Synonyms:667411-75-8;N-(5-Iodo-4-oxo-1,4-dihydropyrimidin-2-yl)benzamide;CTK1H9461;5-Iodo-2-(benzoylamino)pyrimidine-4(3H)-one;DTXSID20459258

Chemical Property of 5-Iodo-2-(benzoylamino)pyrimidine-4(3H)-one

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 340.96612
• Heavy Atom Count: 17
• Complexity: 398

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)NC2=NC=C(C(=O)N2)I

Technology Process of 5-Iodo-2-(benzoylamino)pyrimidine-4(3H)-one

There total 1 articles about 5-Iodo-2-(benzoylamino)pyrimidine-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-amino-5-iodo-4-oxo-3,4-dihydropyrimidine + benzoic acid anhydride (93-97-0) → 2-(N-benzoylamino)-5-iodo-4-oxo-3,4-dihydropyrimidine (667411-75-8)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 1.5h;

DOI:10.1039/b502799c

Reference yield: 68.0%

3,5-bis-O,O-(tert-butyldimethylsilyl)-1,2-didehydro-1,2-dideoxy-D-ribofuranose (173327-56-5) + 2-(N-benzoylamino)-5-iodo-4-oxo-3,4-dihydropyrimidine (667411-75-8) → 2-benzoylamino-5-[2'-deoxy-3',5'-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pent-2-enofuranosyl]-3H-pyrimidin-4-one (667411-76-9)

Guidance literature:

2-(N-benzoylamino)-5-iodo-4-oxo-3,4-dihydropyrimidine; With N,O-bis-(trimethylsilyl)-acetamide; In N,N-dimethyl-formamide; for 1h;

3,5-bis-O,O-(tert-butyldimethylsilyl)-1,2-didehydro-1,2-dideoxy-D-ribofuranose; With palladium diacetate; triphenyl-arsane; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 22h;

DOI:10.1081/NCN-120025239

Reference yield: 63.0%

N-(benzyloxycarbonyl)-(4S)-(tert-butyldimethylsilyloxy)-(5R)-(tert-butyldimethylsilyloxymethyl)-aza-2-cyclopenten (325771-73-1) + 2-(N-benzoylamino)-5-iodo-4-oxo-3,4-dihydropyrimidine (667411-75-8) → (2R,5R)-N-(benzyloxy)carbonyl-2-[2-(N-benzoylamino)-4-oxo-3,4-dihydropyrimidin-5-yl]-4-[(tert-butyl)dimethylsilyl]oxy-5-[(tert-butyl)dimethylsilyl]oxymethyl-aza-cyclopent-3-ene (646521-58-6)

Guidance literature:

2-(N-benzoylamino)-5-iodo-4-oxo-3,4-dihydropyrimidine; With N,O-bis-(trimethylsilyl)-acetamide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

N-(benzyloxycarbonyl)-(4S)-(tert-butyldimethylsilyloxy)-(5R)-(tert-butyldimethylsilyloxymethyl)-aza-2-cyclopenten; With triphenyl-arsane; N-ethyl-N,N-diisopropylamine; palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 22h;

DOI:10.1039/b502799c

upstream raw materials:

benzoic acid anhydride

Downstream raw materials:

2-benzoylamino-5-[2'-deoxy-3',5'-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pent-2-enofuranosyl]-3H-pyrimidin-4-one

(2R,5R)-N-(benzyloxy)carbonyl-2-[2-(N-benzoylamino)-4-oxo-3,4-dihydropyrimidin-5-yl]-4-[(tert-butyl)dimethylsilyl]oxy-5-[(tert-butyl)dimethylsilyl]oxymethyl-aza-cyclopent-3-ene

(2R,4S,5R)-2-[2-(N-benzoylamino)-4-oxo-3,4-dihydropyrimidin-5-yl]-4-hydroxy-5-hydroxymethyl pyrrolidine

(2R,4S,5R)-N-(benzyloxy)carbonyl-2-[2-(N-benzoylamino)-4-oxo-3,4-dihydropyrimidin-5-yl]-4-hydroxy-5-hydroxymethyl pyrrolidine