2-Thiazolidinethione, 3-[(3R)-3-[3-[(1S)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-butynyl]phen yl]-3-hydroxy-1-oxopropyl]-4-(1-methylethyl)-, (4S)-

Base Information

Chemical Name:2-Thiazolidinethione, 3-[(3R)-3-[3-[(1S)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-butynyl]phen yl]-3-hydroxy-1-oxopropyl]-4-(1-methylethyl)-, (4S)-
CAS No.:667419-28-5
Molecular Formula:C₂₅H₃₇NO₃S₂Si
Molecular Weight:491.791
Hs Code.:

2-Thiazolidinethione,
3-[(3R)-3-[3-[(1S)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-butynyl]phen
yl]-3-hydroxy-1-oxopropyl]-4-(1-methylethyl)-, (4S)-

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Chemical Property of 2-Thiazolidinethione, 3-[(3R)-3-[3-[(1S)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-butynyl]phen yl]-3-hydroxy-1-oxopropyl]-4-(1-methylethyl)-, (4S)-

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Technology Process of 2-Thiazolidinethione, 3-[(3R)-3-[3-[(1S)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-butynyl]phen yl]-3-hydroxy-1-oxopropyl]-4-(1-methylethyl)-, (4S)-

There total 8 articles about 2-Thiazolidinethione, 3-[(3R)-3-[3-[(1S)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-butynyl]phen yl]-3-hydroxy-1-oxopropyl]-4-(1-methylethyl)-, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101979-45-7
(S)-3-acetyl-4-isopropyl-1,3-thiazolidine-2-thione

: 667419-27-4
3-[(1S)-1-(tert-butyldimethylsilyloxy)but-3-ynyl]benzaldehyde

: 667419-28-5
(4S)-N-[(3R)-3-[3-((1S)-1-tert-butyldimethylsilyloxy-3-butynyl)phenyl]-3-hydroxypropanoyl]-4-isopropyl-1,3-thiazolidine-2-thione

: (S)-3-{3-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-but-3-ynyl]-phenyl}-3-hydroxy-1-((R)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-propan-1-one

Guidance literature:: With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃;
DOI:10.1016/j.tetlet.2003.11.055

Reference yield:

: 667419-25-2
3-formylbenzyl benzoate

: 667419-28-5
(4S)-N-[(3R)-3-[3-((1S)-1-tert-butyldimethylsilyloxy-3-butynyl)phenyl]-3-hydroxypropanoyl]-4-isopropyl-1,3-thiazolidine-2-thione

Guidance literature:: Multi-step reaction with 5 steps

1.1: (+)-diisopropyl tartrate; molecular sieves A₄ / toluene / -78 °C

1.2: toluene / -78 - 20 °C

2.1: 100 percent / imidazole / dimethylformamide / 2 h / 20 °C

3.1: potassium carbonate / methanol / 1 h / 20 °C

4.1: 3.44 g / 2-iodoxybenzoic acid / dimethylsulfoxide; tetrahydrofuran

5.1: titanium(IV) chloride; diisopropylethylamine / CH₂Cl₂ / cooling

5.2: 74 percent / CH₂Cl₂ / cooling

With 1H-imidazole; L-(+)-diisopropyl tartrate; 4 A molecular sieve; titanium tetrachloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2005.01.062

Reference yield:

: 667419-26-3
(1S)-1-(3-benzoyloxymethylphenyl)-3-butyn-1-ol

: 667419-28-5
(4S)-N-[(3R)-3-[3-((1S)-1-tert-butyldimethylsilyloxy-3-butynyl)phenyl]-3-hydroxypropanoyl]-4-isopropyl-1,3-thiazolidine-2-thione

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / imidazole / dimethylformamide / 2 h / 20 °C

2.1: potassium carbonate / methanol / 1 h / 20 °C

3.1: 3.44 g / 2-iodoxybenzoic acid / dimethylsulfoxide; tetrahydrofuran

4.1: titanium(IV) chloride; diisopropylethylamine / CH₂Cl₂ / cooling

4.2: 74 percent / CH₂Cl₂ / cooling

With 1H-imidazole; titanium tetrachloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.01.062