2-hydroxy-4,6-dimethyl-5-nitronicotinonitrile

Base Information

• Chemical Name: 2-hydroxy-4,6-dimethyl-5-nitronicotinonitrile
• CAS No.: 5407-93-2
• Molecular Formula: C8H7N3O3
• Molecular Weight: 193.1595
• Hs Code.: 2933399090
• Mol file: 5407-93-2.mol

Synonyms:4,6-Dimethyl-heptan-2-on;2-hydroxy-4,6-dimethyl-5-nitro-nicotinonitrile;2-Heptanone,4,6-dimethyl;3-Cyan-4,6-dimethyl-5-nitro-pyrid-2-on;5-Cyan-2,4-dimethyl-3-nitro-pyrid-6-on;4,6-Dimethyl-2-hydroxy-5-nitro-nicotinonitril;4,6-Dimethyl-2-heptanone;4,6-Dimethyl-2-Heptanon;iso-diisobutyl ketone;4,6-dimethyl-heptan-2-one;

Chemical Property of 2-hydroxy-4,6-dimethyl-5-nitronicotinonitrile

Chemical Property:

• Vapor Pressure: 0.000463mmHg at 25°C
• Boiling Point: 314.6°Cat760mmHg
• Flash Point: 144°C
• PSA: 102.47000
• Density: 1.38g/cm³
• LogP: 1.29478

Purity/Quality:

98%min ^*data from raw suppliers

2-Hydroxy-4,6-dimethyl-5-nitronicotinonitrile 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-hydroxy-4,6-dimethyl-5-nitronicotinonitrile

There total 6 articles about 2-hydroxy-4,6-dimethyl-5-nitronicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-Cyano-4,6-dimethyl-2(1H)-pyridon (769-28-8) → 2,4-Dimethyl-3-nitro-5-cyano-6-pyridone (5407-93-2)

Guidance literature:

With sulfuric acid; nitric acid; at 18 - 24 ℃; for 1h;

DOI:10.1007/BF00764185

Reference yield:

2-hydroxy-4,6-dimethyl-3-carbonitrile (769-28-8,70254-47-6) → 2-hydroxy-4,6-dimethyl-5-nitro-nicotinonitrile (5407-93-2)

Guidance literature:

With nitric acid; acetic anhydride;

DOI:10.1021/jo01364a019

Reference yield:

→ 2-hydroxy-4,6-dimethyl-5-nitro-nicotinonitrile (5407-93-2)

Guidance literature:

With nitric acid;

upstream raw materials:

2-hydroxy-4,6-dimethyl-3-carbonitrile

acetylacetone

3-Cyano-4,6-dimethyl-2(1H)-pyridon

Downstream raw materials:

2-chloro-3-cyano-4,6-dimethyl-5-nitropyridine

3-Amino-2,4-dimethyl-5-cyan-pyridin

5-Amino-2-chlor-4,6-dimethyl-nicotinonitril

2-hydroxy-4,6-dimethyl-5-nitro-nicotinic acid

Refernces

• 1、 Mariella et al.. "-". . p. 1721,1727. Retrieved 1955.
• 2、 Dyadyuchenko,Strelkov,Mikhailichenko,Zaplishny. "Synthesis of some halogen- and nitro-substituted nicotinic acids and their fragmentation under electron impact". . p. 308 - 314. Retrieved 2007/10/03.