({[(2S)-1-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid

Base Information

Chemical Name:({[(2S)-1-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
CAS No.:116558-95-3
Molecular Formula:C₉H₁₄N₅O₆P
Molecular Weight:319.214
Hs Code.:
Mol file:116558-95-3.mol

Synonyms:Phosphonicacid, [[(1S)-2-(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-1-(hydroxymethyl)ethoxy]methyl]-(9CI); Phosphonic acid,[[2-(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-1-(hydroxymethyl)ethoxy]methyl]-,(S)-; (S)-9-(3-Hydroxy-2-phosphonomethoxypropyl)guanine;9-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]guanine; HPMPG

Suppliers and Price of ({[(2S)-1-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ({[(2S)-1-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid

Chemical Property:

Vapor Pressure:7.81E-28mmHg at 25°C
Boiling Point:811.6°Cat760mmHg
PKA:2.30±0.10(Predicted)
Flash Point:444.6°C
PSA：187.38000
Density:2.05g/cm³
LogP:-1.44310

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ({[(2S)-1-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid

There total 5 articles about ({[(2S)-1-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 151223-24-4
(R)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>guanine

: 113852-36-1,117086-98-3,138332-09-9,116558-95-3
9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)guanine

Guidance literature:: Multi-step reaction with 2 steps

1: cyclohexene / 20percent Pd(OH)2/C / ethanol / 72 h / Heating

2: bromotrimethylsilane / acetonitrile / 14 h / Ambient temperature

With trimethylsilyl bromide; cyclohexene; palladium dihydroxide; In ethanol; acetonitrile;
DOI:10.1021/jm00094a005

Reference yield:

: 19916-73-5
2-Amino-6-benzyloxypurine

: 113852-36-1,117086-98-3,138332-09-9,116558-95-3
9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)guanine

Guidance literature:: Multi-step reaction with 3 steps

1: cesium carbonate / acetonitrile / 16 h / Heating

2: cyclohexene / 20percent Pd(OH)2/C / ethanol / 72 h / Heating

3: bromotrimethylsilane / acetonitrile / 14 h / Ambient temperature

With trimethylsilyl bromide; caesium carbonate; cyclohexene; palladium dihydroxide; In ethanol; acetonitrile;
DOI:10.1021/jm00094a005

Reference yield:

: 138247-69-5,148873-58-9
(R)-9-<2-<(diisopropylphosphono)methoxy>-3-hydroxypropyl>guanine

: 113852-36-1,117086-98-3,138332-09-9,116558-95-3
9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)guanine

Guidance literature:: With trimethylsilyl bromide; water; Yield given. Multistep reaction; 1.) CH₃CN, RT, overnight, 2.) 30 min;
DOI:10.1135/cccc19930649