Chemical Property of o6-Benzylguanine
Chemical Property:
- Appearance/Colour:light yellow solid
- Vapor Pressure:2.3E-15mmHg at 25°C
- Melting Point:193 °C
- Refractive Index:1.743
- Boiling Point:621.4 °C at 760 mmHg
- PKA:7.47±0.20(Predicted)
- Flash Point:329.6 °C
- PSA：89.71000
- Density:1.431 g/cm3
- LogP:2.09530
- Storage Temp.:-20°C Freezer
- Solubility.:methanol: 20 mg/mL
- XLogP3:1.2
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:3
- Exact Mass:241.09635999
- Heavy Atom Count:18
- Complexity:271
- Purity/Quality:
-
99% *data from raw suppliers
O6-Benzylguanine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC=C(C=C1)COC2=NC(=NC3=C2NC=N3)N
- Recent ClinicalTrials:BG & TMZ Therapy of Glioblastoma Multiforme
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Uses
An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents. O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
