Technology Process of 3-[(3S,5R,8R,9S,10S,13R,17R)-3-[(2R,3R,4S,5S,6R)-5-amino-3,4-dihydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
There total 7 articles about 3-[(3S,5R,8R,9S,10S,13R,17R)-3-[(2R,3R,4S,5S,6R)-5-amino-3,4-dihydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triphenylphosphine;
In
tetrahydrofuran; water;
at 20 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sulfuric acid
2: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; triphenylphosphine / dichloromethane
3: cerium(III) chloride; sodium tetrahydroborate
4: pyridine; dmap / dichloromethane / 3 h / 0 - 20 °C
5: trimethylsilylazide; 1,4-di(diphenylphosphino)-butane; bis(η3-allyl-μ-chloropalladium(II)) / dichloromethane / 3 h / 20 °C
6: osmium(VIII) oxide; 4-methylmorpholine N-oxide; water / acetone; tert-butyl alcohol / 8 h / 0 °C
7: triphenylphosphine / tetrahydrofuran; water / 6 h / 20 °C
With
pyridine; dmap; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium tetrahydroborate; osmium(VIII) oxide; cerium(III) chloride; bis(η3-allyl-μ-chloropalladium(II)); trimethylsilylazide; sulfuric acid; water; 4-methylmorpholine N-oxide; triphenylphosphine; 1,4-di(diphenylphosphino)-butane;
In
tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; triphenylphosphine / dichloromethane
2: cerium(III) chloride; sodium tetrahydroborate
3: pyridine; dmap / dichloromethane / 3 h / 0 - 20 °C
4: trimethylsilylazide; 1,4-di(diphenylphosphino)-butane; bis(η3-allyl-μ-chloropalladium(II)) / dichloromethane / 3 h / 20 °C
5: osmium(VIII) oxide; 4-methylmorpholine N-oxide; water / acetone; tert-butyl alcohol / 8 h / 0 °C
6: triphenylphosphine / tetrahydrofuran; water / 6 h / 20 °C
With
pyridine; dmap; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium tetrahydroborate; osmium(VIII) oxide; cerium(III) chloride; bis(η3-allyl-μ-chloropalladium(II)); trimethylsilylazide; water; 4-methylmorpholine N-oxide; triphenylphosphine; 1,4-di(diphenylphosphino)-butane;
In
tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol;