[1-hydroxy-2-(2-pyridinyl)ethylidene]bis(phosphonic acid)

Base Information

• Chemical Name: [1-hydroxy-2-(2-pyridinyl)ethylidene]bis(phosphonic acid)
• CAS No.: 105462-23-5
• Molecular Formula: C₇H₁₁NO₇P₂
• Molecular Weight: 283.114
• Hs Code.: 2933399090
• Mol file: 105462-23-5.mol

Synonyms:Phosphonicacid, [1-hydroxy-2-(2-pyridinyl)ethylidene]bis- (9CI); NE 58018

Chemical Property of [1-hydroxy-2-(2-pyridinyl)ethylidene]bis(phosphonic acid)

Chemical Property:

• PSA: 167.80000
• LogP: -0.37440

Purity/Quality:

98%Min ^*data from raw suppliers

1-Hydroxy-2-(2-pyridinyl)Risedronate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 8151626
• Hazard Codes: Xi
• Statements: 42/43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Hydroxy-2-(2-pyridinyl) Risedronate is an impurity in the synthesis of Risedronate (R521505), a pyridinyl biphosphonate bone resorption inhibitor.

Technology Process of [1-hydroxy-2-(2-pyridinyl)ethylidene]bis(phosphonic acid)

There total 2 articles about [1-hydroxy-2-(2-pyridinyl)ethylidene]bis(phosphonic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-pyridineacetic acid (13115-43-0) → 1-hydroxy-2-(2-pyridinyl)ethylidene bisphosphonic acid (105462-23-5)

Guidance literature:

2-pyridineacetic acid; With p-cresol; phosphoric acid; phosphorus trichloride; Heating;

With water; Further stages.; Heating;

DOI:10.1080/00397910701578545

Reference yield:

→ 1-hydroxy-2-(2-pyridinyl)ethylidene bisphosphonic acid (105462-23-5)

Guidance literature:

Reference yield:

1-hydroxy-2-(2-pyridinyl)ethylidene bisphosphonic acid (105462-23-5) → 1-hydroxy-2-(2-pyridinyl)ethylidenebisphosphonic acid monosodium (334708-63-3)

Guidance literature:

With sodium hydroxide; In methanol; water; at 0 ℃; for 1h; pH=4.3;

DOI:10.1007/s00044-012-0153-4

upstream raw materials:

2-pyridineacetic acid

Downstream raw materials:

1-hydroxy-2-(2-pyridinyl)ethylidenebisphosphonic acid monosodium

Refernces

• 1、 Rao, Divvela V. N. Srinivasa,Dandala, Ramesh,Narayanan, Garimella K. A. S. S.,Lenin, Racha,Sivakumaran,Naidu, Andra. "Novel procedure for the synthesis of 1-hydroxy-1,1-bisphosphonic acids using phenols as medium". . p. 4359 - 4365. Retrieved 2007.
• 2、 Ghosh, Subhash,Chan, Julian M. W.,Lea, Christopher R.,Meints, Gary A.,Lewis, Jared C.,Tovian, Zev S.,Flessner, Ryan M.,Loftus, Timothy C.,Bruchhaus, Iris,Kendrick, Howard,Croft, Simon L.,Kemp, Robert G.,Kobayashi, Seike,Nozaki, Tomoyoshi,Oldfield, Eric. "Effects of Bisphosphonates on the Growth of Entamoeba histolytica and Plasmodium Species in Vitro and in Vivo". . p. 175 - 187. Retrieved 2007/10/03.