2-Pyridylacetic acid

Base Information

• Chemical Name: 2-Pyridylacetic acid
• CAS No.: 13115-43-0
• Molecular Formula: C7H7NO2
• Molecular Weight: 137.138
• Hs Code.: 2933399090
• Mol file: 13115-43-0.mol

Synonyms:(2-Pyridinyl)aceticacid;2-(2-Pyridyl)acetic acid;2-(Pyridin-2-yl)acetic acid;2-Pyridylaceticacid;2-Pyridylacetic acid;

Chemical Property of 2-Pyridylacetic acid

Chemical Property:

• Vapor Pressure: 0.00235mmHg at 25°C
• Refractive Index: 1.557
• Boiling Point: 276.173 °C at 760 mmHg
• PKA: 3.30±0.10(Predicted)
• Flash Point: 120.825 °C
• PSA: 50.19000
• Density: 1.246 g/cm³
• LogP: 0.70870
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Pyridin-2-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridylacetic acid

There total 15 articles about 2-Pyridylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 2-(pyridinyl-2)acetate (2739-98-2) → 2-pyridineacetic acid (13115-43-0)

Guidance literature:

With water; potassium hydroxide; In ethanol; at 50 ℃; for 0.5h;

Reference yield: 90.0%

2-bromo-pyridine (109-04-6) + bromoacetic acid tert-butyl ester (5292-43-3) → 2-pyridineacetic acid (13115-43-0)

Guidance literature:

bromoacetic acid tert-butyl ester; With iodine; zinc; In tetrahydrofuran; at 100 ℃; for 0.0833333h; microwave irradiation;

2-bromo-pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 120 ℃; for 0.0833333h; Further stages.; microwave irradiation;

DOI:10.1016/j.tetlet.2004.08.074

Reference yield:

2-(2-Hydroxyethyl)pyridine (103-74-2) → 2-Picolinic acid (98-98-6) + 2-pyridineacetic acid (13115-43-0)

Guidance literature:

With sodium hydroxide; at 50 ℃; Title compound not separated from byproducts.; Electrochemical reaction;

DOI:10.1007/s11172-007-0079-z

upstream raw materials:

ethyl 2-(pyridinyl-2)acetate

N-phenyl-2-(pyridin-2-yl)acetamide

3,5-dimethylphenyl 2-pyridylacetate

2-bromo-pyridine

Downstream raw materials:

piperidin-2-yl-acetic acid methyl ester

2-(piperidin-2-yl)acetic acid

piperidin-2-yl-acetic acid hydrochloride

Refernces

• 1、 Bartlett, E. M.,Johnson, M. D.. "". . . Retrieved 1970.
• 2、 Pohl,Waldmann. "Enhancement of the enantioselectivity of penicillin G acylase from E. coli by 'substrate tuning'". . p. 2963 - 2966. Retrieved 1995.
• 3、 Baruah, Pranjal K.,Dinsmore, Jason,King, Amber M.,Salomé, Christophe,De Ryck, Marc,Kaminski, Rafal,Provins, Laurent,Kohn, Harold. "Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides". supporting information; experimental part. p. 3551 - 3564. Retrieved 2012/07/28.
• 4、 Lyalin,Petrosyan. "Electrosynthesis of arylalkanoic acids by oxidation of the corresponding arylalkanols at the Ni anode in aqueous alkali". . p. 499 - 503. Retrieved 2008/04/05.