2,5-Dimethylfuran-3-carboxamide

Base Information

• Chemical Name: 2,5-Dimethylfuran-3-carboxamide
• CAS No.: 66806-31-3
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.15200
• Hs Code.: 2932190090
• European Community (EC) Number: 622-120-8
• Mol file: 66806-31-3.mol

Synonyms:2,5-dimethylfuran-3-carboxamide;66806-31-3;2,5-dimethyl-3-furamide;SCHEMBL5799680;AKOS008977413

Chemical Property of 2,5-Dimethylfuran-3-carboxamide

Chemical Property:

• PSA: 57.22000
• LogP: 1.87950
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 147

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(O1)C)C(=O)N

Technology Process of 2,5-Dimethylfuran-3-carboxamide

There total 4 articles about 2,5-Dimethylfuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dimethyl-furan-3-carbonyl chloride (50990-93-7) → 2,5-dimethylfuran-3-carboxamide (66806-31-3)

Guidance literature:

With ammonium hydroxide; In dichloromethane; water; at 0 - 20 ℃; for 1h;

DOI:10.1039/c8md00474a

Reference yield:

2,5-dimethylfuran-3-carboxylic acid (636-44-2) → 2,5-dimethylfuran-3-carboxamide (66806-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 2 h / Reflux

2: ammonium hydroxide / water; dichloromethane / 1 h / 0 - 20 °C

With ammonium hydroxide; thionyl chloride; In dichloromethane; water; toluene;

DOI:10.1039/c8md00474a

Reference yield:

2,5-dimethyl-furan-3-carbonitrile (89149-69-9) → 2,5-dimethylfuran-3-carboxamide (66806-31-3)

Guidance literature:

With potassium hydroxide;

upstream raw materials:

2,5-dimethyl-furan-3-carbonitrile

2-acetyl-4-oxopentanenitrile

2,5-dimethyl-furan-3-carbonyl chloride

2,5-dimethylfuran-3-carboxylic acid

Downstream raw materials:

(2,5-dimethylfuran-3-yl)methanamine