636-44-2

Basic information

• Product Name: 2,5-DIMETHYL-3-FUROIC ACID
• Synonyms: TIMTEC-BB SBB004165;2,5-DIMETHYLFURAN-3-CARBOXYLIC ACID;2,5-DIMETHYL-3-FUROIC ACID;2,5-DIMETHYL-3-FURANCARBOXYLIC ACID;pyrotritaric acid;2,5-DIMETHYL-3-FUORIC ACID;2,5-Dimethyl-3-furoic acid,98%;2,5-Dimethyl-3-furoic acid2,5-Dimethylfuran-3-carboxylic acid
• CAS NO: 636-44-2
• Molecular Formula: C₇H₈O₃
• Molecular Weight: 140.14
• EINECS: 211-257-5
• Product Categories: Carboxylic Acids;Furans, Benzofurans & Dihydrobenzofurans;Carboxylic Acids;Furans, Benzofurans & Dihydrobenzofurans
• Mol File: 636-44-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 137-140 °C(lit.)
• Boiling Point: 240.6 °C at 760 mmHg
• Flash Point: 99.3 °C
• Appearance: white to faint yellow crystalline powder
• Density: 1.194 g/cm³
• Vapor Pressure: 0.0204mmHg at 25°C
• PKA: 4.56±0.26(Predicted)
• CAS DataBase Reference: 2,5-DIMETHYL-3-FUROIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHYL-3-FUROIC ACID(636-44-2)
• EPA Substance Registry System: 2,5-DIMETHYL-3-FUROIC ACID(636-44-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 3261
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 636-44-2(Hazardous Substances Data)

Usage

Uses

2,5-Dimethyl-3-furoic acid may be used as carboxylato ligand in the preparation of the following titanocene complexes:[Ti(η5-C5H5)2(OOC-dmf)2][Ti(η5-C5H4Me)2(OOC-dmf)2]

InChI:InChI=1/C7H8O3/c1-4-3-6(7(8)9)5(2)10-4/h3H,1-2H3,(H,8,9)/p-1

Upstream product

• 6148-34-1 methyl 2,5-dimethylfuran-3-carboxylate 
• 29113-63-1 ethyl 2,5-dimethyl-3-furoate 
• 625-86-5 2,5-dimethylfuran 
• 127-17-3 2-oxo-propionic acid 
• 141-97-9 ethyl acetoacetate 
• 598-31-2 1-bromoacetone 
• 18152-79-9 ethyl 3-bromo-4,6-dimethyl-2-oxo-2H-pyran-5-carboxylate 
• 64-17-5 ethanol 
• 127-09-3 sodium acetate 
• 41892-81-3 ethyl 2-acetyl-4-oxopentanoate 
• 36600-70-1 ethyl 2-acetylpent-4-ynoate 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 10599-70-9 2,5-dimethyl-3-acetylfuran 

Downstream Products

• 29113-63-1 ethyl 2,5-dimethyl-3-furoate 
• 110-13-4 2,5-hexanedione 

Relevant articles and documents

Benzene sulfonamide compound and application of compound in preparing anti-influenza A virus drug

The invention discloses a benzene sulfonamide compound and an application of the compound in preparing an anti-influenza A virus drug and belongs to the technical field of pharmaceuticals. A structural formula of the benzene sulfonamide compound is shown as formula (I) as shown in the specification, and the benzene sulfonamide compound is prepared by preparing a corresponding furoyl chloride compound, a thiophenecarbonyl chloride compound and a benzothiophene formyl chloride compound from a furoic acid compound, a thiophenic acid compound or a thionaphthencarboxylic acid compound under the backflow conditions of thionyl chloride and methylbenzene, further performing amination reaction to form a corresponding furoylamide compound, a thiophenecarboxamide compound and a benzothiophene formamide compound, reducing to a corresponding furylmethylamine compound, a thienylmethylamine compound and a benzothiophene methylamine compound under the condition of lithium aluminium hydride, and performing sulfonylation reaction under the conditions of taking triethylamine as an acid-binding agent and dichloromethane as a solvent. The benzene sulfonamide compound can effectively inhibit activity ofan influenza A virus, is low in cytotoxicity and can be used for preparing the anti-influenza A virus drug.

Design, synthesis and antifungal activity of novel furancarboxamide derivatives

Twenty-seven novel furancarboxamide derivatives with a diphenyl ether moiety were synthesized and evaluated for their antifungal activity against Rhizoctonia solani, Botrytis cirerea, Valsa Mali and Sphaceloma ampelimum. Antifungal bioassay results indicated that most compounds had good or excellent fungicidal activities for R. solani and S. ampelimum at 20 mg L-1. Among synthesized compounds, compound 18e showed a greater inhibitory effect against S. ampelimum, with half maximal effective concentration (EC50) values of 0.020 mg L-1. This strong activity rivals currently used commercial fungicides, such as Boscalid and Carbendazim, and has great potential as a lead compound for future development of novel fungicides.

A simple preparation of ethyl 2,5-dimethylfuran-3-carboxylate and 2,5-dimethylfuran-3,4-dicarboxylic acid from diethyl 2,3-diacetylsuccinate

(Chemical Equation Presented) A simple preparation of ethyl 2,5-dimethylfuran-3-carboxylate (3), 2,5-dimethylfuran-3,4-dicarboxylic acid (4), and diethyl 2,5-dimethylfuran-3,4-dicarboxylate (5) by treatment of diethyl 2,3-diacetylsuccinate (2) with aqueous HCl is reported. The reaction is performed under organic solvent free conditions from a readily available cheap starting material.