(2R)-N-Methyl-2-PyrrolidinecarboxaMide

Base Information

• Chemical Name: (2R)-N-Methyl-2-PyrrolidinecarboxaMide
• CAS No.: 66877-05-2
• Molecular Formula: C6H12N2O
• Molecular Weight: 128.17200
• Mol file: 66877-05-2.mol

Synonyms:(R)-N-Methyl-2-pyrrolidinecarboxamide HCl;N-METHYL-D-PROLINAMIDE;

Chemical Property of (2R)-N-Methyl-2-PyrrolidinecarboxaMide

Chemical Property:

• PSA: 41.13000
• LogP: 0.20410

Purity/Quality:

99.90% ^*data from raw suppliers

(R)-N-Methyl-2-pyrrolidinecarboxamide HCl 95+% ee ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R)-N-Methyl-2-PyrrolidinecarboxaMide

There total 3 articles about (2R)-N-Methyl-2-PyrrolidinecarboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl (2R)-2-(methylcarbamoyl)pyrrolidine-1-carboxylate (66877-06-3) → (R)-proline methylamide (66877-05-2)

Guidance literature:

With 10% palladium on carbon; hydrogen; In methanol; for 7h;

DOI:10.1016/j.ejmech.2008.12.022

Reference yield:

Z-D-proline (6404-31-5) → (R)-proline methylamide (66877-05-2)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 7 h / 0 - 25 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;

Reference yield:

→ (R)-proline methylamide (66877-05-2)

Guidance literature:

Z-D-Pro-OH, 1.) Et3N, Chlorameisensaeureester, Methylamin, 2.) PdO, Hydrierung;

upstream raw materials:

benzyl (2R)-2-(methylcarbamoyl)pyrrolidine-1-carboxylate

Z-D-proline

Refernces

• 1、 Diakos, Connie I.,Zhang, Mei,Beale, Philip J.,Fenton, Ronald R.,Hambley, Trevor W.. "Synthesis, characterisation and in vitro cytotoxicity studies of a series of chiral platinum(II) complexes based on the 2-aminomethylpyrrolidine ligand: X-ray crystal structure of [PtCl2(R-dimepyrr)] (R-dimepyrr = N-dimethyl-2(R)-aminomethylpyrrolidine)". experimental part. p. 2807 - 2814. Retrieved 2009/10/10.