4-BROMO-PYRIDINE-2,6-DICARBOXYLIC ACID DIAMIDE

Base Information

• Chemical Name: 4-BROMO-PYRIDINE-2,6-DICARBOXYLIC ACID DIAMIDE
• CAS No.: 668992-72-1
• Molecular Formula: C7H6BrN3O2
• Molecular Weight: 244.048
• Hs Code.: 29333990
• Mol file: 668992-72-1.mol

Synonyms:4-Bromopyridazine hydrochloride;4-bromopyridine-2,6-biscarbonamide;

Chemical Property of 4-BROMO-PYRIDINE-2,6-DICARBOXYLIC ACID DIAMIDE

Chemical Property:

• Boiling Point: 413.2±45.0 °C(Predicted)
• PKA: 13.71±0.50(Predicted)
• PSA: 100.06000
• Density: 1.791±0.06 g/cm3(Predicted)
• LogP: 1.62640

Purity/Quality:

98% ^*data from raw suppliers

4-Bromopyridine-2,6-dicarboxamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-PYRIDINE-2,6-DICARBOXYLIC ACID DIAMIDE

There total 5 articles about 4-BROMO-PYRIDINE-2,6-DICARBOXYLIC ACID DIAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

diethyl 4-bromo-2,6-pyridinedicarboxylate (112776-83-7) → 4-bromopyridine-2,6-biscarbonamide (668992-72-1)

Guidance literature:

With ammonia; In methanol; for 1.5h; Inert atmosphere;

DOI:10.1002/chem.201900450

Reference yield: 78.0%

dimethyl 4-bromo-2,6-pyridinedicarboxylate (162102-79-6) → 4-bromopyridine-2,6-biscarbonamide (668992-72-1)

Guidance literature:

With ammonium hydroxide; In methanol; dichloromethane; water; at 20 ℃;

DOI:10.1039/d1dt00726b

Reference yield:

Chelidamic acid (499-51-4) → 4-bromopyridine-2,6-biscarbonamide (668992-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: phosphorus pentabromide / 3 h / 90 °C

1.2: 70 percent / CHCl₃

2.1: ammonia / methanol / 3 h / Heating

With ammonia; phosphorus pentabromide; In methanol;

DOI:10.1021/ol036279g

upstream raw materials:

dimethyl 4-bromo-2,6-pyridinedicarboxylate

Chelidamic acid

diethyl 4-bromo-2,6-pyridinedicarboxylate

4-bromopyridine-2,6-dicarbonyl dibromide

Downstream raw materials:

4-bromo-pyridine-2,6-diamine