Dimethyl 2-bromo-2,6-pyridinedicarboxylate

Base Information

• Chemical Name: Dimethyl 2-bromo-2,6-pyridinedicarboxylate
• CAS No.: 162102-79-6
• Molecular Formula: C9H8BrNO4
• Molecular Weight: 274.071
• Hs Code.: 29333990
• Mol file: 162102-79-6.mol

Synonyms:2,6-Pyridinedicarboxylicacid, 4-bromo-, dimethyl ester (9CI);4-Bromo-2,6-pyridinedicarboxylic aciddimethyl ester;Dimethyl 4-bromo-2,6-pyridinedicarboxylate;

Chemical Property of Dimethyl 2-bromo-2,6-pyridinedicarboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 176 °C
• Refractive Index: 1.549
• Boiling Point: 369.566 °C at 760 mmHg
• PKA: -2.40±0.10(Predicted)
• Flash Point: 177.308 °C
• PSA: 65.49000
• Density: 1.569g/cm³
• LogP: 1.41730
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Dimethyl4-bromopyridine-2,6-dicarboxylate 95% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

Useful:

Technology Process of Dimethyl 2-bromo-2,6-pyridinedicarboxylate

There total 12 articles about Dimethyl 2-bromo-2,6-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

dimethyl 4-hydroxypyridine-2,6-dicarboxylate (19872-91-4) → dimethyl 4-bromo-2,6-pyridinedicarboxylate (162102-79-6)

Guidance literature:

With phosphorus pentoxide; tetrabutylammomium bromide; In toluene; for 3h;

DOI:10.1002/cphc.202000071

Reference yield: 94.0%

methanol (67-56-1) + chelidamic acid (138-60-3) → dimethyl 4-bromo-2,6-pyridinedicarboxylate (162102-79-6)

Guidance literature:

chelidamic acid; With phosphorus pentabromide; at 90 ℃; for 2h;

methanol; In chloroform; at 20 ℃; for 20h; Cooling with ice;

Reference yield: 93.0%

methanol (67-56-1) + Chelidamic acid (499-51-4) → dimethyl 4-bromo-2,6-pyridinedicarboxylate (162102-79-6)

Guidance literature:

Chelidamic acid; With phosphorus pentabromide; at 80 ℃; for 2h;

methanol; In chloroform; at 0 - 20 ℃;

upstream raw materials:

methanol

4-bromopyridine-2,6-dicarboxylic acid

4-oxo-1,4-dihydro-pyridine-2,6-dicarboxylic acid dimethyl ester

Chelidamic acid

Downstream raw materials:

dimethyl 4-(4-aminophenylethynyl)-2,6-pyridinedicarboxylate

4-bromo-2,6-pyridinedimethanol

4-bromopyridine-2,6-biscarbonamide

4-vinyl-2,6-dimethyldipicolinate