Technology Process of Butanamide,
N-[3-[(3Z,5R,6S,7S)-7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,6-dimeth
yl-9-oxo-5-[[tris(1-methylethyl)silyl]oxy]-3-nonenyl]-2,5-dimethoxyphenyl]-
3-methoxy-4-oxo-N-[(2,2,2-trichloroethoxy)methyl]-, (3R)-
There total 23 articles about Butanamide,
N-[3-[(3Z,5R,6S,7S)-7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,6-dimeth
yl-9-oxo-5-[[tris(1-methylethyl)silyl]oxy]-3-nonenyl]-2,5-dimethoxyphenyl]-
3-methoxy-4-oxo-N-[(2,2,2-trichloroethoxy)methyl]-, (3R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine-SO3 complex; triethylamine;
In
dimethyl sulfoxide;
at 20 ℃;
for 1.33333h;
DOI:10.1021/ol036284k
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 100 percent / H2 / Pd/C / methanol / 1.5 h
2.1: Et3N; ClCO2Et / CH2Cl2 / 0.67 h / -20 °C
2.2: 91 percent / NH3 gas / CH2Cl2 / -10 °C
3.1: 82 percent / K2CO3; CuI; N,N'-dimethylethylenediamine / toluene / 36 h / 110 °C
4.1: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C
4.2: 73 percent / tetrahydrofuran / 8 h / -78 - -30 °C
5.1: 96 percent / Na2HPO4; Na/Hg / methanol / 1.5 h / -20 °C
6.1: KH / tetrahydrofuran / 0.15 h / 0 °C
6.2: 95 percent / tetrahydrofuran / 0.33 h / 20 °C
7.1: 91 percent / HF*pyr / pyridine; tetrahydrofuran / 2 h / 0 - 20 °C
8.1: 91 percent / Et3N; SO3*pyr / dimethylsulfoxide / 1.33 h / 20 °C
With
disodium hydrogenphosphate; sodium amalgam; copper(l) iodide; pyridine-SO3 complex; hydrogen; chloroformic acid ethyl ester; potassium hydride; potassium carbonate; pyridine hydrogenfluoride; triethylamine; lithium hexamethyldisilazane; N,N`-dimethylethylenediamine;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; methanol; dichloromethane; dimethyl sulfoxide; toluene;
8.1: Parikh-Doering oxidation;
DOI:10.1021/ol036284k
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: 89 percent / AcONa; Br2 / acetic acid / 1 h / 20 °C
2.1: 99 percent / K2CO3 / dimethylformamide / 24 h / 20 °C
3.1: 100 percent / BH3*THF / tetrahydrofuran / 1 h / 0 °C
4.1: 96 percent / PPh4; CBr4 / tetrahydrofuran / 1 h / 20 °C
5.1: 86 percent / dimethylformamide / 24 h / 20 °C
6.1: 82 percent / K2CO3; CuI; N,N'-dimethylethylenediamine / toluene / 36 h / 110 °C
7.1: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C
7.2: 73 percent / tetrahydrofuran / 8 h / -78 - -30 °C
8.1: 96 percent / Na2HPO4; Na/Hg / methanol / 1.5 h / -20 °C
9.1: KH / tetrahydrofuran / 0.15 h / 0 °C
9.2: 95 percent / tetrahydrofuran / 0.33 h / 20 °C
10.1: 91 percent / HF*pyr / pyridine; tetrahydrofuran / 2 h / 0 - 20 °C
11.1: 91 percent / Et3N; SO3*pyr / dimethylsulfoxide / 1.33 h / 20 °C
With
disodium hydrogenphosphate; sodium amalgam; copper(l) iodide; borane-THF; pyridine-SO3 complex; carbon tetrabromide; bromine; sodium acetate; tetraphenylphosphonium; potassium hydride; potassium carbonate; pyridine hydrogenfluoride; triethylamine; lithium hexamethyldisilazane; N,N`-dimethylethylenediamine;
In
tetrahydrofuran; pyridine; methanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
11.1: Parikh-Doering oxidation;
DOI:10.1021/ol036284k
![[1(3Z,5R,6S,7S),3R]-N-{3-[7-(tert-butyl-dimethylsilyloxy)-9-hydroxy-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-hydroxy-3-methoxy-N-(2,2,2-trichloroethoxymethyl)-butyramide](/Databaselist/images/loading.webp)
