5-broMo-3-fluoropyridine-2-carbaldehyde

Base Information

• Chemical Name: 5-broMo-3-fluoropyridine-2-carbaldehyde
• CAS No.: 669066-93-7
• Molecular Formula: C6H3BrFNO
• Molecular Weight: 203.998
• Hs Code.: 2933399990
• Mol file: 669066-93-7.mol

Synonyms:5-BROMO-3-FLUOROPICOLINALDEHYDE;5-BROMO-3-FLUOROPYRIDINE-2-CARBOXALDEHYDE;

Chemical Property of 5-broMo-3-fluoropyridine-2-carbaldehyde

Chemical Property:

• Vapor Pressure: 0.125mmHg at 25°C
• Boiling Point: 218.5oC at 760 mmHg
• PKA: -1.10±0.10(Predicted)
• Flash Point: 86oC
• PSA: 29.96000
• Density: 1.778g/cm3
• LogP: 1.79570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

5-Bromo-3-fluoropicolinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-broMo-3-fluoropyridine-2-carbaldehyde

There total 8 articles about 5-broMo-3-fluoropyridine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.7%

5-bromo-3-fluoro-N-methoxy-N-methylpicolinamide (669066-92-6) → 5-bromo-3-fluoropyridine-2-carboxaldehyde (669066-93-7)

Guidance literature:

With lithium aluminium hydride; In tetrahydrofuran; at -70 ℃; for 2.25h;

Reference yield:

5-bromo-3-fluoropyridine-2-carbonitrile (886373-28-0) → 5-bromo-3-fluoropyridine-2-carboxaldehyde (669066-93-7)

Guidance literature:

5-bromo-3-fluoropyridine-2-carbonitrile; With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 - 0 ℃;

With hydrogenchloride; In dichloromethane; water; toluene; at -78 ℃;

Reference yield:

5-bromo-3-fluoro-pyridine-2-carboxylic acid (669066-91-5) → 5-bromo-3-fluoropyridine-2-carboxaldehyde (669066-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1: EDCI; TEA / dimethylformamide

2: LiAlH₄ / diethyl ether / -78 °C

With lithium aluminium hydride; TEA; N-[3-(N,N-dimethylamino)-propyl]-N'-ethyl-carbodiimide hydrochloride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.04.040

upstream raw materials:

5-bromo-3-fluoro-N-methoxy-N-methylpicolinamide

5-bromo-3-fluoro-pyridine-2-carboxylic acid amide

5-bromo-3-fluoro-pyridine-2-carboxylic acid

3-amino-5-bromopyridine-2-carboxylic acid amide

Downstream raw materials:

C₁₉H₂₂ClFN₂O₃S

C₁₅H₁₄ClFN₂O₂

C₁₉H₂₁Cl₂FN₂O₃S

C₁₅H₁₃Cl₂FN₂O₂

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