1-Boc-4-(4-chlorophenyl)4-piperidinemethanamine

Base Information

• Chemical Name: 1-Boc-4-(4-chlorophenyl)4-piperidinemethanamine
• CAS No.: 669068-16-0
• Molecular Formula: C17H25ClN2O2
• Molecular Weight: 324.851
• Mol file: 669068-16-0.mol

Synonyms:4-aminomethyl-4-(4-chloro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester;4-AMINOMETHYL-4-(4-CHLOROPHENYL)PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-N-BOC-4-aminomethyl-4-(4-chlorophenyl)piperidine;

Chemical Property of 1-Boc-4-(4-chlorophenyl)4-piperidinemethanamine

Chemical Property:

• PSA: 55.56000
• LogP: 4.20560

Purity/Quality:

95%-98% ^*data from raw suppliers

4-Aminomethyl-4-(4-chloro-phenyl)-piperidine-1-carboxylicacidtert-butylester 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-4-(4-chlorophenyl)4-piperidinemethanamine

There total 4 articles about 1-Boc-4-(4-chlorophenyl)4-piperidinemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-(4-chloro-phenyl)-4-cyano-piperidine-1-carboxylic acid tert-butyl ester (218451-34-4) → 4-aminomethyl-4-(4-chlorophenyl)piperidine-1-carboxylic acid tert-butyl ester (669068-16-0)

Guidance literature:

With hydrogen; nickel; In ethanol; at 20 ℃; for 20h; under 760.051 Torr;

DOI:10.1021/jm701437d

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 4-aminomethyl-4-(4-chlorophenyl)piperidine-1-carboxylic acid tert-butyl ester (669068-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / dichloromethane / 18.5 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 90 h / 20 - 65 °C

3: hydrogen / nickel / ethanol / 20 h / 20 °C / 760.05 Torr

With sodium hydroxide; hydrogen; sodium hydride; nickel; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine (118753-70-1) → 4-aminomethyl-4-(4-chlorophenyl)piperidine-1-carboxylic acid tert-butyl ester (669068-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 90 h / 20 - 65 °C

2: hydrogen / nickel / ethanol / 20 h / 20 °C / 760.05 Torr

With hydrogen; sodium hydride; nickel; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

4-(4-chloro-phenyl)-4-cyano-piperidine-1-carboxylic acid tert-butyl ester

di-tert-butyl dicarbonate

N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine

Downstream raw materials:

C-(4-(4-chlorophenyl)piperidin-4-yl)methylamine

4-(4-chloro-phenyl)-4-{[3-(2,4-dimethoxy-benzyl)-4-oxo-3,4-dihydro-quinazolin-7-ylamino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester

C₂₇H₂₃ClN₄O₂

2-[4-(4-chlorophenyl)-piperidin-4-ylmethyl]-isoindole-1,3-dione

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