218451-34-4

Basic information

• Product Name: TERT-BUTYL 4-(4-CHLOROPHENYL)-4-CYANOPIPERIDINE-1-CARBOXYLATE
• Synonyms: TERT-BUTYL 4-(4-CHLOROPHENYL)-4-CYANOPIPERIDINE-1-CARBOXYLATE;1-Boc-4-cyano-4-(4-chlorophenyl)-piperidine
• CAS NO: 218451-34-4
• Molecular Formula: C₁₇H₂₁ClN₂O₂
• Molecular Weight: 320.81
• Mol File: 218451-34-4.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: TERT-BUTYL 4-(4-CHLOROPHENYL)-4-CYANOPIPERIDINE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-(4-CHLOROPHENYL)-4-CYANOPIPERIDINE-1-CARBOXYLATE(218451-34-4)
• EPA Substance Registry System: TERT-BUTYL 4-(4-CHLOROPHENYL)-4-CYANOPIPERIDINE-1-CARBOXYLATE(218451-34-4)

Safety Data

• Hazardous Substances Data: 218451-34-4(Hazardous Substances Data)

Upstream product

• 118753-70-1 N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine 
• 140-53-4 p-chlorobenzyl cyanide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 623-03-0 4-Cyanochlorobenzene 

Downstream Products

• 91721-16-3 4-(4-chlorophenyl)piperidine-4-carbonitrile 
• 669068-16-0 4-aminomethyl-4-(4-chlorophenyl)piperidine-1-carboxylic acid tert-butyl ester 
• 885500-46-9 tert-butyl 4-(4-chlorophenyl)-4-formylpiperidine-1-carboxylate 
• 644981-94-2 4-(4-chloro-phenyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 
• 849106-03-2 4-carbamoyl-4-(4-chloro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 672927-26-3 4-(4-chloro-phenyl)-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester 
• 672927-27-4 [4-(4-chloro-phenyl)-piperidin-4-yl]-methanol 
• 849106-01-0 4-(4-chloro-phenyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester 

Relevant articles and documents

Substituted p-chlorophenyl acetylpiperazine-containing compound as well as preparation method and application thereof

The application provides a substituted p-chlorophenyl acetylpiperazine-containing compound as well as a preparation method and application of the substituted p-chlorophenyl acetylpiperazine-containingcompound. The compound has the structure shown in the formula (I), and has better Akt1 inhibitory activity or growth inhibitory activity to MCL cell lines.

TRIAZOLOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF

Provided are triazolopyridine compounds that are inhibitors of JAK kinase, such as JAK1, compositions containing these compounds and methods for treating diseases mediated by a JAK kinase. In particular, provided are compounds of formula (I), stereoisomer

A nitrogen-containing heterocyclic phenyl piperidine compound and its preparation method and application

The invention discloses a nitrogen-containing heterocyclic phenyl piperidine compound or pharmaceutical salt thereof. The general structural formula a of the compound is as shown in specification, wherein R represents hydrogen, mono-substituted or poly-substituted halogen, methyl, methoxyl, tertiary butyl or trifluoromethyl; and R2 is hydrogen, chlorine, bromine, methyl or ethyl. The compound disclosed by the invention is novel in structure; and by introducing the active amino in the form of a piperidine ring, the configuration of the side-chain amino is reinforced and the rigidity of the compound is enhanced. Through the design transformation, the Akt1 kinase inhibitory activity and the PC-3 cell line growth inhibitory activity of the compound are significantly enhanced.