2-(2-(tert-Butylamino)-1-hydroxyethyl)-7-benzofuranyl methyl ketone

Base Information

• Chemical Name: 2-(2-(tert-Butylamino)-1-hydroxyethyl)-7-benzofuranyl methyl ketone
• CAS No.: 84952-27-2
• Molecular Formula: C₁₆H₂₁NO₃
• Molecular Weight: 275.348
• Mol file: 84952-27-2.mol

Synonyms:Ethanone,1-[2-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-7-benzofuranyl]-, (R)-

Chemical Property of 2-(2-(tert-Butylamino)-1-hydroxyethyl)-7-benzofuranyl methyl ketone

Chemical Property:

• Vapor Pressure: 4.61E-08mmHg at 25°C
• Boiling Point: 427.3°Cat760mmHg
• Flash Point: 212.2°C
• PSA: 62.47000
• Density: 1.129g/cm³
• LogP: 3.44780

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-(tert-Butylamino)-1-hydroxyethyl)-7-benzofuranyl methyl ketone

There total 5 articles about 2-(2-(tert-Butylamino)-1-hydroxyethyl)-7-benzofuranyl methyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5(R)-(7-acetyl-2-benzofuranyl)-3-tert-butyl-2-oxazolidinone (97733-13-6,1246819-44-2) → 2-<2-(tert-butylamino)-1(R)-hydroxyethyl>-7-benzofuranyl methyl ketone (84952-27-2)

Guidance literature:

With potassium hydroxide; In methanol; for 8h; Heating;

DOI:10.1021/jm00149a018

Reference yield:

(+)-Bufuralol (64100-61-4) → 2-<2-(tert-butylamino)-1(R)-hydroxyethyl>-7-benzofuranyl methyl ketone (84952-27-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / sodium methoxide / 0.25 h

2: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 6 h / 52 °C / Irradiation

3: sodium carbonate / tetrahydrofuran; H₂O / 24 h / 60 °C

4: 85 percent / pyridinium chlorochromate / CH₂Cl₂ / 1 h / Heating

5: 10 M KOH / methanol / 8 h / Heating

With potassium hydroxide; N-Bromosuccinimide; sodium methylate; sodium carbonate; pyridinium chlorochromate; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water;

DOI:10.1021/jm00149a018

Reference yield:

3-tert-butyl-5(R)-(7-ethyl-2-benzofuranyl)-2-oxazolidinone (97749-44-5,1076199-68-2) → 2-<2-(tert-butylamino)-1(R)-hydroxyethyl>-7-benzofuranyl methyl ketone (84952-27-2)

Guidance literature:

Multi-step reaction with 4 steps

1: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 6 h / 52 °C / Irradiation

2: sodium carbonate / tetrahydrofuran; H₂O / 24 h / 60 °C

3: 85 percent / pyridinium chlorochromate / CH₂Cl₂ / 1 h / Heating

4: 10 M KOH / methanol / 8 h / Heating

With potassium hydroxide; N-Bromosuccinimide; sodium carbonate; pyridinium chlorochromate; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water;

DOI:10.1021/jm00149a018

upstream raw materials:

5(R)-(7-acetyl-2-benzofuranyl)-3-tert-butyl-2-oxazolidinone

(+)-Bufuralol

3-tert-butyl-5(R)-(7-ethyl-2-benzofuranyl)-2-oxazolidinone

3-tert-butyl-5(R)-<7-(1-hydroxyethyl)-2-benzofuranyl>-oxazolidinone

Refernces