Methyl 6-cyano-7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-2-carboxylate

Base Information

Chemical Name:Methyl 6-cyano-7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-2-carboxylate
CAS No.:66917-18-8
Molecular Formula:C12H10N2O4
Molecular Weight:246.21900
Hs Code.:
DSSTox Substance ID:DTXSID10573972
Mol file:66917-18-8.mol

Synonyms:66917-18-8;6-Cyano-1,2,3,5-tetrahydro-7-methyl-1,5-dioxo-2-Indolizinecarboxylic Acid Methyl Ester;Methyl 6-cyano-7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-2-carboxylate;methyl 6-cyano-7-methyl-1,5-dioxo-2,3-dihydroindolizine-2-carboxylate;DTXSID10573972;Methyl6-cyano-7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-2-carboxylate

Suppliers and Price of Methyl 6-cyano-7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Cyano-1,2,3,5-tetrahydro-7-methyl-1,5-dioxo-2-IndolizinecarboxylicAcidMethylEster
250mg
$ 165.00

Biosynth Carbosynth
6-Cyano-1,2,3,5-tetrahydro-7-methyl-1,5-dioxo-2-indolizinecarboxylic acid methyl ester
10 mg
$ 149.90

Biosynth Carbosynth
6-Cyano-1,2,3,5-tetrahydro-7-methyl-1,5-dioxo-2-indolizinecarboxylic acid methyl ester
250 mg
$ 1640.00

Biosynth Carbosynth
6-Cyano-1,2,3,5-tetrahydro-7-methyl-1,5-dioxo-2-indolizinecarboxylic acid methyl ester
100 mg
$ 901.00

Biosynth Carbosynth
6-Cyano-1,2,3,5-tetrahydro-7-methyl-1,5-dioxo-2-indolizinecarboxylic acid methyl ester
50 mg
$ 496.00

Biosynth Carbosynth
6-Cyano-1,2,3,5-tetrahydro-7-methyl-1,5-dioxo-2-indolizinecarboxylic acid methyl ester
25 mg
$ 272.50

Total 3 raw suppliers

Chemical Property of Methyl 6-cyano-7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-2-carboxylate

Chemical Property:

Boiling Point:485.6±45.0 °C(Predicted)
PKA:10.06±0.60(Predicted)
PSA：89.16000
Density:1.41±0.1 g/cm3(Predicted)
LogP:0.01388
Solubility.:Dimethyl Sulfoxide
XLogP3:0
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:246.06405680
Heavy Atom Count:18
Complexity:576

Purity/Quality:

97% ^*data from raw suppliers

6-Cyano-1,2,3,5-tetrahydro-7-methyl-1,5-dioxo-2-IndolizinecarboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=O)N2CC(C(=O)C2=C1)C(=O)OC)C#N
Uses Intermediate in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents.

Technology Process of Methyl 6-cyano-7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-2-carboxylate

There total 1 articles about Methyl 6-cyano-7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122-51-0
orthoformic acid triethyl ester

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 615-79-2
ethyl 2,4-diketopentanoate

: 107-91-5
cyanoacetic acid amide

: 66917-18-8
2-(methoxycarbonyl)-6-cyano-7-methyl-1,5-dioxo-Δ6(8)-tetrahydroindolizine

Guidance literature:: orthoformic acid triethyl ester; ethyl 2,4-diketopentanoate; toluene-4-sulfonic acid; In ethanol; at 42 - 44 ℃; for 1h;

cyanoacetic acid amide; With potassium carbonate; In dimethyl sulfoxide; at 68 - 71 ℃; for 3h;

acrylic acid methyl ester; at 68 - 70 ℃; for 6h;