L-Serine, O-[(1,1-dimethylethyl)diphenylsilyl]-N-[[2-[(1S,2R)-2-hydroxy-1-[[(phenyl methoxy)carbonyl]amino]propyl]-5-methyl-4-oxazolyl]carbonyl]-, methyl ester

Base Information

Chemical Name:L-Serine, O-[(1,1-dimethylethyl)diphenylsilyl]-N-[[2-[(1S,2R)-2-hydroxy-1-[[(phenyl methoxy)carbonyl]amino]propyl]-5-methyl-4-oxazolyl]carbonyl]-, methyl ester
CAS No.:670233-36-0
Molecular Formula:C₃₆H₄₃N₃O₈Si
Molecular Weight:673.838
Hs Code.:

L-Serine,
O-[(1,1-dimethylethyl)diphenylsilyl]-N-[[2-[(1S,2R)-2-hydroxy-1-[[(phenyl
methoxy)carbonyl]amino]propyl]-5-methyl-4-oxazolyl]carbonyl]-, methyl
ester

Synonyms:

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Chemical Property of L-Serine, O-[(1,1-dimethylethyl)diphenylsilyl]-N-[[2-[(1S,2R)-2-hydroxy-1-[[(phenyl methoxy)carbonyl]amino]propyl]-5-methyl-4-oxazolyl]carbonyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of L-Serine, O-[(1,1-dimethylethyl)diphenylsilyl]-N-[[2-[(1S,2R)-2-hydroxy-1-[[(phenyl methoxy)carbonyl]amino]propyl]-5-methyl-4-oxazolyl]carbonyl]-, methyl ester

There total 7 articles about L-Serine, O-[(1,1-dimethylethyl)diphenylsilyl]-N-[[2-[(1S,2R)-2-hydroxy-1-[[(phenyl methoxy)carbonyl]amino]propyl]-5-methyl-4-oxazolyl]carbonyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 670233-35-9
(4'S,5'R)-4-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methoxycarbonyl-ethylcarbamoyl]-5,2',2',5'-tetramethyl-4',5'-dihydro-[2,4']bioxazolyl-3'-carboxylic acid benzyl ester

: 670233-36-0
(S)-2-{[2-((1S,2R)-1-Benzyloxycarbonylamino-2-hydroxy-propyl)-5-methyl-oxazole-4-carbonyl]-amino}-3-(tert-butyl-diphenyl-silanyloxy)-propionic acid methyl ester

Guidance literature:: With trifluoroacetic acid; In chloroform;
DOI:10.1246/cl.2004.72

Reference yield:

: 160821-18-1
(4S,5R)-3-((benzyloxy)carbonyl)-2,2,5-trimethyloxazolidine-4-carboxylic acid

: 670233-36-0
(S)-2-{[2-((1S,2R)-1-Benzyloxycarbonylamino-2-hydroxy-propyl)-5-methyl-oxazole-4-carbonyl]-amino}-3-(tert-butyl-diphenyl-silanyloxy)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 92 percent / DCC; HOBt / dimethylformamide

2.1: MsCl; NEt₃ / CHCl₃

2.2: DBU / CHCl₃

3.1: NBS / tetrahydrofuran

3.2: Et₃N / tetrahydrofuran

4.1: Cs₂CO₃ / dioxane

5.1: 100 percent / LiOH / dioxane; H₂O

6.1: DPPA; Et₃N / dimethylformamide

7.1: TFA / CHCl₃

With lithium hydroxide; N-Bromosuccinimide; diphenyl-phosphinic acid; benzotriazol-1-ol; caesium carbonate; methanesulfonyl chloride; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1246/cl.2004.72

Reference yield:

: (4S,5R)-4-((Z)-1-Methoxycarbonyl-propenylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid benzyl ester

: 670233-36-0
(S)-2-{[2-((1S,2R)-1-Benzyloxycarbonylamino-2-hydroxy-propyl)-5-methyl-oxazole-4-carbonyl]-amino}-3-(tert-butyl-diphenyl-silanyloxy)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: NBS / tetrahydrofuran

1.2: Et₃N / tetrahydrofuran

2.1: Cs₂CO₃ / dioxane

3.1: 100 percent / LiOH / dioxane; H₂O

4.1: DPPA; Et₃N / dimethylformamide

5.1: TFA / CHCl₃

With lithium hydroxide; N-Bromosuccinimide; diphenyl-phosphinic acid; caesium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1246/cl.2004.72