5-(2-METHOXYPHENYL)-1,3,4-OXADIAZOL-2-AMINE

Base Information

• Chemical Name: 5-(2-METHOXYPHENYL)-1,3,4-OXADIAZOL-2-AMINE
• CAS No.: 5711-59-1
• Molecular Formula: C9H9N3O2
• Molecular Weight: 191.189
• Hs Code.: 2934999090
• Mol file: 5711-59-1.mol

Synonyms:F2146-0067;5-(o-Methoxyphenyl)-2-amino-1,3,4-oxadiazol;5-(2-methoxy-phenyl)-[1,3,4]oxadiazol-2-ylamine;5-(2-Methoxy-phenyl)-2-amino-1,3,4-oxdiazol;2-Amino-5-(o-methoxyphenyl)-1,3,4-oxadiazole;2-Amino-5-(2-methoxyphenyl)-1,3,4-oxadiazol;1,3,4-Oxadiazole,2-amino-5-(o-methoxyphenyl);

Chemical Property of 5-(2-METHOXYPHENYL)-1,3,4-OXADIAZOL-2-AMINE

Chemical Property:

• Vapor Pressure: 5.64E-06mmHg at 25°C
• Boiling Point: 380°C at 760 mmHg
• Flash Point: 183.6°C
• PSA: 74.17000
• Density: 1.272g/cm³
• LogP: 1.90860

Purity/Quality:

98%Min ^*data from raw suppliers

5-(2-Methoxyphenyl)-1,3,4-oxadiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-METHOXYPHENYL)-1,3,4-OXADIAZOL-2-AMINE

There total 6 articles about 5-(2-METHOXYPHENYL)-1,3,4-OXADIAZOL-2-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-methoxybenzaldehyde semicarbazone (120445-51-4,5346-30-5) → 2-amino-5-(2-methoxyphenyl)-1,3,4-oxadiazole (5711-59-1)

Guidance literature:

With acetic acid; at 20 ℃; for 4h;

Reference yield:

N1-(o-methoxybenzoyl)-3-thiosemicarbazide (7653-42-1) → 2-amino-5-(2-methoxyphenyl)-1,3,4-oxadiazole (5711-59-1)

Guidance literature:

With water; iodine; potassium iodide; sodium hydroxide; In ethanol; at 70 ℃;

DOI:10.1039/c3ra41044g

Reference yield:

2-methoxybenzoylhydrazine (7466-54-8) → 2-amino-5-(2-methoxyphenyl)-1,3,4-oxadiazole (5711-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 70 °C

2: sodium hydroxide; potassium iodide; iodine; water / ethanol / 70 °C

With water; iodine; potassium iodide; sodium hydroxide; In ethanol;

DOI:10.1039/c3ra41044g

upstream raw materials:

bromocyane

2-methoxybenzoylhydrazine

2-methoxybenzaldehyde semicarbazone

N¹-(o-methoxybenzoyl)-3-thiosemicarbazide

Downstream raw materials:

1-(2-Methoxy-benzoyl)-5-carbamoyl-diaminoguanidin

[5-(2-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-carbamic acid ethyl ester

1-(4-fluoro-phenyl)-3-[5-(2-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-urea