1-(4-fluoro-phenyl)-3-[5-(2-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-urea

Base Information

Chemical Name:1-(4-fluoro-phenyl)-3-[5-(2-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-urea
CAS No.:312324-92-8
Molecular Formula:C₁₆H₁₃FN₄O₃
Molecular Weight:328.303
Hs Code.:

Synonyms:1-(4-fluoro-phenyl)-3-[5-(2-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-fluoro-phenyl)-3-[5-(2-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-urea

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Technology Process of 1-(4-fluoro-phenyl)-3-[5-(2-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-urea

There total 3 articles about 1-(4-fluoro-phenyl)-3-[5-(2-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 371-40-4
4-fluoroaniline

: 312324-90-6
[5-(2-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-carbamic acid ethyl ester

: 312324-92-8
1-(4-fluoro-phenyl)-3-[5-(2-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-urea

Guidance literature:: In ethanol; for 16h; Heating;
DOI:10.1021/jf990742f

Reference yield:

: 5711-59-1
2-amino-5-(2-methoxyphenyl)-1,3,4-oxadiazole

: 312324-92-8
1-(4-fluoro-phenyl)-3-[5-(2-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-urea

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; Et₃N / 1 h / Heating

2: 59 percent / ethanol / 16 h / Heating

With pyridine; triethylamine; In ethanol;
DOI:10.1021/jf990742f

Reference yield:

: 120445-51-4,5346-30-5
2-methoxybenzaldehyde semicarbazone

: 312324-92-8
1-(4-fluoro-phenyl)-3-[5-(2-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-urea

Guidance literature:: Multi-step reaction with 3 steps

1: Br₂; NaOAc; AcOH

2: pyridine; Et₃N / 1 h / Heating

3: 59 percent / ethanol / 16 h / Heating

With pyridine; bromine; sodium acetate; acetic acid; triethylamine; In ethanol;
DOI:10.1021/jf990742f