Ethanone, 2-amino-1-(2,5-dimethoxyphenyl)-, hydrochloride

Base Information

• Chemical Name: Ethanone, 2-amino-1-(2,5-dimethoxyphenyl)-, hydrochloride
• CAS No.: 671224-08-1
• Molecular Formula: C₁₀H₁₃NO₃*ClH
• Molecular Weight: 231.679
• Hs Code.: 2922509090
• Mol file: 671224-08-1.mol

Synonyms:2-amino-1-(2,5-dimethoxyphenyl)ethanone,hydrochloride;

Chemical Property of Ethanone, 2-amino-1-(2,5-dimethoxyphenyl)-, hydrochloride

Chemical Property:

• PSA: 61.55000
• LogP: 2.34750

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-1-(2,5-dimethoxyphenyl)ethanonehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 2-amino-1-(2,5-dimethoxyphenyl)-, hydrochloride

There total 3 articles about Ethanone, 2-amino-1-(2,5-dimethoxyphenyl)-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-bromo-2',5'-dimethoxyacetophenone (1204-21-3) → 2-amino-1-(2,5-dimethoxyphenyl)ethanone hydrochloride (671224-08-1)

Guidance literature:

2-bromo-2',5'-dimethoxyacetophenone; With hexamethylenetetramine; In tetrahydrofuran; water; at 20 ℃; for 2h;

With hydrogenchloride; water; In methanol; for 1h; Heating / reflux;

Reference yield: 85.0%

hexamethylenetetramine (100-97-0) + 2-bromo-2',5'-dimethoxyacetophenone (1204-21-3) → 2-amino-1-(2,5-dimethoxyphenyl)ethanone hydrochloride (671224-08-1)

Guidance literature:

hexamethylenetetramine; 2-bromo-2',5'-dimethoxyacetophenone; In tetrahydrofuran; water; at 20 ℃; for 2h;

With hydrogenchloride; In methanol; water; for 1h; Heating / reflux;

Reference yield:

2-azido-1-(2,5-dimethoxyphenyl)ethanone → 2-amino-1-(2,5-dimethoxyphenyl)ethanone hydrochloride (671224-08-1)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; diethyl ether; at 20 ℃; for 5h; under 2250.23 Torr;

DOI:10.1002/chem.200700594

upstream raw materials:

hexamethylenetetramine

2-bromo-2',5'-dimethoxyacetophenone

Refernces

• 1、 -. "AN IMPROVED PROCESS FOR THE SYNTHESIS OF (±) 2-AMINO-N-[2,(S,5-DIMETHOXYPHENYL)-2-HYDROXYETHYL] ACETAMIDE MONOHYDROCHLORIDE". Page 7-8; 3. . Retrieved 2008/06/13.