2-Propenoic acid, 3-[4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymeth yl)-1-pyrrolidinyl]-5-pyrimidinyl]-2-methyl-, ethyl ester

Base Information

• Chemical Name: 2-Propenoic acid, 3-[4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymeth yl)-1-pyrrolidinyl]-5-pyrimidinyl]-2-methyl-, ethyl ester
• CAS No.: 671753-59-6
• Molecular Formula: C23H29ClN4O4
• Molecular Weight: 460.961

Synonyms:

Chemical Property of 2-Propenoic acid, 3-[4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymeth yl)-1-pyrrolidinyl]-5-pyrimidinyl]-2-methyl-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 3-[4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymeth yl)-1-pyrrolidinyl]-5-pyrimidinyl]-2-methyl-, ethyl ester

There total 1 articles about 2-Propenoic acid, 3-[4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymeth yl)-1-pyrrolidinyl]-5-pyrimidinyl]-2-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[2-(3-Chloro-4-methoxy-benzylamino)-6-methanesulfinyl-pyridin-3-yl]-2-methyl-acrylic acid ethyl ester (454486-77-2) + (S)-1-Pyrrolidin-2-yl-methanol (23356-96-9) → 3-[4-(3-Chloro-4-methoxy-benzylamino)-2-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-pyrimidin-5-yl]-2-methyl-acrylic acid ethyl ester (671753-59-6)

Guidance literature:

With triethylamine; In chloroform; for 6h; Heating / reflux;

Reference yield:

3-[4-(3-Chloro-4-methoxy-benzylamino)-2-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-pyrimidin-5-yl]-2-methyl-acrylic acid ethyl ester (671753-59-6) → (S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-6-methyl-8-(3-chloro-4-methoxybenzyl)-7,8-dihydro-7-oxo-pyrido[2,3-d]pyrimidine

Guidance literature:

With sodium hydride; In methanol; for 6h; Heating / reflux;

upstream raw materials:

3-[2-(3-Chloro-4-methoxy-benzylamino)-6-methanesulfinyl-pyridin-3-yl]-2-methyl-acrylic acid ethyl ester

(S)-1-Pyrrolidin-2-yl-methanol

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