Technology Process of 2H-Pyran-2-one, tetrahydro-6-[2-(4-methoxyphenoxy)ethyl]-5-methyl-,
(5S,6R)-
There total 5 articles about 2H-Pyran-2-one, tetrahydro-6-[2-(4-methoxyphenoxy)ethyl]-5-methyl-,
(5S,6R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-pyridylmethyl formate; triethyl{(1R,2S)-1-[2-(4-methoxyphenoxy)ethyl]-2-methylbut-3-enyloxy}silane;
dodecacarbonyl-triangulo-triruthenium;
at 135 ℃;
for 16.5h;
With
acetic acid;
In
tetrahydrofuran; water;
at 20 ℃;
for 18h;
DOI:10.1021/ol036339i
- Guidance literature:
-
2-pyridylmethyl formate; (3R,4S)-1-(4-methoxyphenoxy)-4-methylhex-5-en-3-ol;
dodecacarbonyl-triangulo-triruthenium;
at 135 ℃;
for 15.5h;
With
acetic acid;
In
tetrahydrofuran; water;
at 85 ℃;
for 24h;
DOI:10.1021/ol036339i
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: O3 / methanol / -42 °C
1.2: 56 percent / Me2S / methanol / 3 h / -42 - 20 °C
2.1: (4R,trans)-2,2-Me2-tetraphenyl-1,3-dioxolane-4,5-dimethanol; CpTiCl3 / tetrahydrofuran; diethyl ether / 3.5 h / -78 - 0 °C
2.2: 96 percent / diethyl ether / 0.33 h / -78 °C
3.1: 94 percent / imidazole / CH2Cl2 / 1 h / 20 °C
4.1: Ru3(CO)12 / 16.5 h / 135 °C
4.2: 68 percent / HOAc / tetrahydrofuran; H2O / 18 h / 20 °C
With
1H-imidazole; cyclopentadienyl titanium(IV) trichloride; (S,S)-taddol; ozone;
dodecacarbonyl-triangulo-triruthenium;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol036339i
