Heptanamide, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1-methyl-2 -phenylethyl]-7-(4-methoxyphenoxy)-N,4-dimethyl-, (4S,5R)-

Base Information

Chemical Name:Heptanamide, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1-methyl-2 -phenylethyl]-7-(4-methoxyphenoxy)-N,4-dimethyl-, (4S,5R)-
CAS No.:671798-90-6
Molecular Formula:C31H49NO5Si
Molecular Weight:543.819
Hs Code.:

Heptanamide,
5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1-methyl-2
-phenylethyl]-7-(4-methoxyphenoxy)-N,4-dimethyl-, (4S,5R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Heptanamide, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1-methyl-2 -phenylethyl]-7-(4-methoxyphenoxy)-N,4-dimethyl-, (4S,5R)-

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Technology Process of Heptanamide, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1-methyl-2 -phenylethyl]-7-(4-methoxyphenoxy)-N,4-dimethyl-, (4S,5R)-

There total 6 articles about Heptanamide, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1-methyl-2 -phenylethyl]-7-(4-methoxyphenoxy)-N,4-dimethyl-, (4S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 671799-04-5
(4S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxyphenoxy)-4-methylheptanoic acid pyridin-2-ylmethyl ester

: 671798-90-6
(4R,5S)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxyphenoxy)-4-methylheptanoic acid [(1S,2S)-(2-hydroxy-1-methyl-2-phenylethyl)]methylamine

Guidance literature:: pseudoephedrine; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.75h;

(4S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxyphenoxy)-4-methylheptanoic acid pyridin-2-ylmethyl ester; In tetrahydrofuran; at 0 ℃; for 0.666667h;
DOI:10.1021/ol036339i

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 671798-90-6
(4R,5S)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxyphenoxy)-4-methylheptanoic acid [(1S,2S)-(2-hydroxy-1-methyl-2-phenylethyl)]methylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 86 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 0 °C

2.1: 80 percent / Ru₃(CO)12 / 15.5 h / 135 °C

3.1: NaH / tetrahydrofuran / 0.75 h / 0 °C

3.2: 83 percent / tetrahydrofuran / 0.67 h / 0 °C

With 2,6-dimethylpyridine; dodecacarbonyl-triangulo-triruthenium; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol036339i

Reference yield:

: 2653-90-9
1-(but-3-en-1-yloxy)-4-methoxybenzene

: 671798-90-6
(4R,5S)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxyphenoxy)-4-methylheptanoic acid [(1S,2S)-(2-hydroxy-1-methyl-2-phenylethyl)]methylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: O₃ / methanol / -42 °C

1.2: 56 percent / Me₂S / methanol / 3 h / -42 - 20 °C

2.1: (4R,trans)-2,2-Me₂-tetraphenyl-1,3-dioxolane-4,5-dimethanol; CpTiCl₃ / tetrahydrofuran; diethyl ether / 3.5 h / -78 - 0 °C

2.2: 96 percent / diethyl ether / 0.33 h / -78 °C

3.1: 86 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 0 °C

4.1: 80 percent / Ru₃(CO)12 / 15.5 h / 135 °C

5.1: NaH / tetrahydrofuran / 0.75 h / 0 °C

5.2: 83 percent / tetrahydrofuran / 0.67 h / 0 °C

With 2,6-dimethylpyridine; dodecacarbonyl-triangulo-triruthenium; cyclopentadienyl titanium(IV) trichloride; sodium hydride; (S,S)-taddol; ozone; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol036339i