Pseudoephedrine

Base Information Edit

Chemical Name:Pseudoephedrine
CAS No.:90-82-4
Deprecated CAS:304-87-0,30987-59-8,37577-31-4,30987-59-8,37577-31-4
Molecular Formula:C10H15NO
Molecular Weight:165.235
Hs Code.:
European Community (EC) Number:202-018-6
UNII:7CUC9DDI9F
DSSTox Substance ID:DTXSID0023537
Nikkaji Number:J10.171K
Wikipedia:Pseudoephedrine
Wikidata:Q263958
NCI Thesaurus Code:C61914
RXCUI:8896
Pharos Ligand ID:1HFKNVHKHTY2
Metabolomics Workbench ID:37948
ChEMBL ID:CHEMBL1590
Mol file:90-82-4.mol

Synonyms:Ephedrine Threo Isomer;Isoephedrine;Pseudoephedrine;Pseudoephedrine HCl;Pseudoephedrine Hydrochloride;Sudafed;Threo Isomer of Ephedrine

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Pseudoephedrine Edit

Chemical Property:

Appearance/Colour:white crystals
Vapor Pressure:0.00865mmHg at 25°C
Melting Point:118-120 °C
Refractive Index:1.528
Boiling Point:255 °C at 760 mmHg
PKA:pKa 9.73(H2O,t=25±0.5,I=0.01)(Approximate)
Flash Point:85.6 °C
Density:1.015 g/cm³
Storage Temp.:?20°C
Water Solubility.:<0.5g/L(er)
XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:165.115364102
Heavy Atom Count:12
Complexity:121

Purity/Quality:

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn,T,F
Statements: 20/21/22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements: 26-37/39-45-36/37-16-7

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(C1=CC=CC=C1)O)NC
Isomeric SMILES:C[C@@H]([C@H](C1=CC=CC=C1)O)NC
Recent ClinicalTrials:A Study of Continuous Blood Pressure Monitoring in Healthy Participants
Recent EU Clinical Trials:A randomized, double-blind, placebo-controlled crossover study to assess the efficacy's reproducibility of a combination of Pseudoephedrine and Cetirizine on symptom scores and rhinomanometry in patients with allergic rhinitis following pollen exposure in the Fraunhofer Environmental Challenge Chamber (ECC) in- and outside the grass pollen season
Description Pseudoephedrine is a stereoisomer of ephedrine, in the drug class of sympathomimetics. It occurs naturally in plants of the genus Ephedra. Pseudoephedrine is a mixed-acting decongestant, which activates α- and β-adrenergic receptors directly by binding to the receptor itself, and indirectly by causing norepinephrine release in synaptic nerve terminals. Pseudoephedrine is also used illicitly in the production of methamphetamine. In the United States, two recent acts of legislation – the Combat Methamphetamine Epidemic Act of 2005 and the Methamphetamine Production Prevention Act of 2008– have created stringent regulation on the sale of pseudoephedrine without a prescription. Pseudoephedrine-containing products were moved behind the counter, only to be sold by the pharmacist using their professional judgment and discretion. Limitations on the quantity of pseudoephedrine that could be purchased at one time and over a period of timewere enacted, and strict record keeping was required. (1S,2S)-(+)-Pseudoephedrine (Item No. 14209) is an analytical reference standard that is categorized as an amphetamine. (1S,2S)-(+)-Pseudoephedrine is a precursor in the synthesis of methamphetamine (Item Nos. 13997 | 13998 | ISO60168). This product is intended for research and forensic applications.
Uses Pseudoephedrine is an orally active sympathomimetic amine that is used as a nasal decongestant. It exerts its decongestant action by acting directly on a-adrenergic receptors in the respiratory tract mucosa producing vasoconstriction resulting in shrinkage of swollen nasal mucous membranes, reduction of tissue hyperemia, edema, and nasal congestion, and an increase in nasal airway patency. Drainage of sinus secretions is increased and obstructed eustachian ostia may be opened. Relaxation of bronchial smooth muscle by stimulation of b-adrenergic receptors may also occur.

Technology Process of Pseudoephedrine

There total 146 articles about Pseudoephedrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 552-79-4,1201-56-5,14222-20-9,17605-71-9,39263-91-7,42151-56-4,51018-28-1,62560-55-8,87040-40-2
(+/-)-erythro-methylephedrine

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 90-81-3,90-82-4,299-42-3,321-97-1,321-98-2,4125-58-0,34783-90-9,38732-95-5,53214-57-6,7009-81-6,90-83-5,6912-63-6
ephedrine

: 100-52-7
benzaldehyde

: 75-07-0,9002-91-9
acetaldehyde

: 124-40-3
dimethyl amine

Guidance literature:: With water; at 25 ℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines;