(1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid

Base Information

• Chemical Name: (1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid
• CAS No.: 671815-99-9
• Molecular Formula: C14H25NO4
• Molecular Weight: 271.357
• Mol file: 671815-99-9.mol

Synonyms:4-[(1R)-1-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]cyclohexane-1-carboxylic acid;

Chemical Property of (1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid

Chemical Property:

• Melting Point: 125-128°C
• Boiling Point: 416.1±18.0 °C(Predicted)
• PKA: 4.85±0.10(Predicted)
• PSA: 79.12000
• Density: 1.088±0.06 g/cm3(Predicted)
• LogP: 2.99500
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Ethyl Acetate

Purity/Quality:

99.3% ^*data from raw suppliers

(1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylicAcid(~90%R) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters.

Technology Process of (1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid

There total 18 articles about (1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(1R,4r)-methyl 4-((R)-1-((tert-butoxycarbonyl)amino)ethyl)cyclohexanecarboxylate → (1R,4r)-4-((R)-1-((tert-butoxycarbonyl)amino)ethyl)cyclohexanecarboxylic acid (671815-99-9)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 0 - 25 ℃; for 2h;

Reference yield: 89.0%

di-tert-butyl dicarbonate (24424-99-5) + trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid (149004-75-1) → (1R,4r)-4-((R)-1-((tert-butoxycarbonyl)amino)ethyl)cyclohexanecarboxylic acid (671815-99-9)

Guidance literature:

trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid; With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 0.5h;

di-tert-butyl dicarbonate; In tetrahydrofuran; water; at 20 ℃; for 48h;

With hydrogenchloride; In water; for 3 - 4h;

DOI:10.1039/c1ob05332a

Reference yield: 83.0%

C14H25NO3 → (1R,4r)-4-((R)-1-((tert-butoxycarbonyl)amino)ethyl)cyclohexanecarboxylic acid (671815-99-9)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; In water; acetonitrile; tert-butyl alcohol; at 20 ℃; for 0.5h;

upstream raw materials:

di-tert-butyl dicarbonate

trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid

(R)-1-phenyl-ethyl-amine

N-acetyl-1-phenylethylamine

Downstream raw materials:

trans-tert-butyl (R)-1-[4-(pyridin-4-ylcarbamoyl)cyclohexyl]ethylcarbamate

(R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide dihydrochloride

C₁₉H₂₈FN₃O₃

C₁₉H₂₈FN₃O₃

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