Ethyl 5,6,7,8-tetrahydroiMidazo[1,2-a]pyridine-2-carboxylate

Base Information

• Chemical Name: Ethyl 5,6,7,8-tetrahydroiMidazo[1,2-a]pyridine-2-carboxylate
• CAS No.: 67286-71-9
• Molecular Formula: C10H14N2O2
• Molecular Weight: 194.23000
• Hs Code.: 2933990090
• Mol file: 67286-71-9.mol

Synonyms:tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazinecarboxylate-2 d'ethyle;ethyl imidazo-<1,2a>-5,6,7,8-tetrahydropyridine-2-carboxylate;

Chemical Property of Ethyl 5,6,7,8-tetrahydroiMidazo[1,2-a]pyridine-2-carboxylate

Chemical Property:

• Melting Point: 59-63 °C
• Boiling Point: 367.4±15.0 °C(Predicted)
• PKA: 4.39±0.20(Predicted)
• PSA: 44.12000
• Density: 1.25±0.1 g/cm3(Predicted)
• LogP: 1.39610
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

ethyl5H,6H,7H,8H-imidazo[1,2-a]pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of Ethyl 5,6,7,8-tetrahydroiMidazo[1,2-a]pyridine-2-carboxylate

There total 6 articles about Ethyl 5,6,7,8-tetrahydroiMidazo[1,2-a]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.81%

ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate (38922-77-9) → ethyl imidazo-<1,2a>-5,6,7,8-tetrahydropyridine-2-carboxylate (67286-71-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; In tetrahydrofuran; ethanol; for 16h; under 3750.38 Torr;

Reference yield:

ethyl 2-benzenehydrazonyl-3-piperidiniumpropanoate tetrafluoroborate → ethyl imidazo-<1,2a>-5,6,7,8-tetrahydropyridine-2-carboxylate (67286-71-9)

Guidance literature:

With triethylamine; In acetonitrile; for 2h; Heating;

DOI:10.1016/S0040-4020(01)98869-6

Reference yield:

2-aminopyridine (504-29-0) → ethyl imidazo-<1,2a>-5,6,7,8-tetrahydropyridine-2-carboxylate (67286-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 5 h / Reflux

2: acetic acid; palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 16 h / 3750.38 Torr

With palladium 10% on activated carbon; hydrogen; acetic acid; In tetrahydrofuran; ethanol;

upstream raw materials:

ethyl (E)-3-(piperidin-1-yl)acrylate

benzenediazonium tetrafluoroborate

2-aminopyridine

ethyl Bromopyruvate

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