4H-1-Benzopyran-4-one, 6-ethyl-2,3-dihydro-

Base Information

• Chemical Name: 4H-1-Benzopyran-4-one, 6-ethyl-2,3-dihydro-
• CAS No.: 672904-14-2
• Molecular Formula: C11H12O2
• Molecular Weight: 176.21200
• Mol file: 672904-14-2.mol

Synonyms:

Chemical Property of 4H-1-Benzopyran-4-one, 6-ethyl-2,3-dihydro-

Chemical Property:

• PSA: 26.30000
• LogP: 2.21420

Purity/Quality:

97% ^*data from raw suppliers

6-ethylchroman-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-1-Benzopyran-4-one, 6-ethyl-2,3-dihydro-

There total 4 articles about 4H-1-Benzopyran-4-one, 6-ethyl-2,3-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-(4-ethyl-phenoxy)-propionic acid (358351-16-3) → 6-ethylchroman-4-one (672904-14-2)

Guidance literature:

3-(4-ethyl-phenoxy)-propionic acid; With thionyl chloride; for 2h; Heating / reflux;

With aluminum (III) chloride; In dichloromethane; for 14h; Heating / reflux;

With hydrogenchloride; In dichloromethane; water;

Reference yield: 52.0%

1-(3-bromo-5-ethyl-2-methoxyphenyl)ethan-1-one → 6-ethylchroman-4-one (672904-14-2)

Guidance literature:

With palladium⁽⁰⁾bis(tricyclohexylphosphine); 1-Adamantanecarboxylic acid; caesium carbonate; In toluene; at 120 ℃; for 16h; Inert atmosphere; Sealed tube; Glovebox;

DOI:10.1002/anie.201908460

Reference yield:

3-ethyl-6-hydroxyacetophenone (24539-92-2) → 6-ethylchroman-4-one (672904-14-2)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide

2: potassium carbonate / acetone

3: palladium⁽⁰⁾bis(tricyclohexylphosphine); 1-Adamantanecarboxylic acid; caesium carbonate / toluene / 16 h / 120 °C / Inert atmosphere; Sealed tube; Glovebox

With N-Bromosuccinimide; palladium⁽⁰⁾bis(tricyclohexylphosphine); 1-Adamantanecarboxylic acid; potassium carbonate; caesium carbonate; In N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1002/anie.201908460

upstream raw materials:

3-(4-ethyl-phenoxy)-propionic acid

3-ethyl-6-hydroxyacetophenone

1-(3-bromo-5-ethyl-2-hydroxyphenyl)ethan-1-one