5'-Ethyl-2'-hydroxyacetophenone

Base Information

• Chemical Name: 5'-Ethyl-2'-hydroxyacetophenone
• CAS No.: 24539-92-2
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• Hs Code.: 2914501900
• European Community (EC) Number: 672-548-4
• DSSTox Substance ID: DTXSID70374523
• Nikkaji Number: J2.511.353E
• Wikidata: Q82163142
• Mol file: 24539-92-2.mol

Synonyms:5'-Ethyl-2'-hydroxyacetophenone;24539-92-2;1-(5-ethyl-2-hydroxyphenyl)ethanone;1-(2-hydroxy-5-ethylphenyl)ethanone;5-ethyl-2-hydroxyacetophenone;1-(5-ethyl-2-hydroxyphenyl)ethan-1-one;MFCD00053308;Ethanone,1-(5-ethyl-2-hydroxyphenyl)-;Ethanone, 1-(5-ethyl-2-hydroxyphenyl)-;SCHEMBL925372;2'-hydroxy-5'-ethylacetophenone;DTXSID70374523;GSTOHKXQBZZTPF-UHFFFAOYSA-N;AKOS005261408;CS-W001511;FS-1296;FT-0638430;EN300-22398;S10957;A817352

Chemical Property of 5'-Ethyl-2'-hydroxyacetophenone

Chemical Property:

• Vapor Pressure: 0.00346mmHg at 25°C
• Refractive Index: 1.539
• Boiling Point: 273.3 °C at 760 mmHg
• PKA: 10.50±0.18(Predicted)
• Flash Point: 114.1 °C
• PSA: 37.30000
• Density: 1.078 g/cm³
• LogP: 2.15720
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 164.083729621
• Heavy Atom Count: 12
• Complexity: 165

Purity/Quality:

97% ^*data from raw suppliers

5''-Ethyl-2’-hydroxyacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CC(=C(C=C1)O)C(=O)C

Technology Process of 5'-Ethyl-2'-hydroxyacetophenone

There total 8 articles about 5'-Ethyl-2'-hydroxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

p-ethylphenyl acetate (3245-23-6,746657-65-8) → 3-ethyl-6-hydroxyacetophenone (24539-92-2)

Guidance literature:

With aluminium trichloride; 1.) 70 -> 80 deg C, 2 h, 2.) 120 deg C, 40 min;

DOI:10.1055/s-1982-30007

Reference yield: 71.0%

4-Ethylphenol (123-07-9) + acetyl chloride (75-36-5) → 3-ethyl-6-hydroxyacetophenone (24539-92-2)

Guidance literature:

With aluminium trichloride; In 1,2-dichloro-ethane; at 110 - 120 ℃; for 8h;

Reference yield: 36.0%

1-methyl-1,3-bis(trimethylsilyloxy)buta-1,3-diene (63446-76-4,63446-77-5,68225-97-8) + 2-(diethoxymethyl)-1,1-diethoxybutane (30989-69-6) → 3-ethyl-6-hydroxyacetophenone (24539-92-2)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at -78 - 20 ℃; for 14h;

DOI:10.1021/jo070847e

upstream raw materials:

p-ethylphenyl acetate

4-Ethylphenol

acetyl chloride

1-methyl-1,3-bis(trimethylsilyloxy)buta-1,3-diene

Downstream raw materials:

5-ethyl-2-hydroxy-3-nitroacetophenone

2-(2-Benzenesulfinyl-1-hydroxy-1-methyl-allyl)-4-ethyl-phenol

E-1-(2'-hydroxy-5'-ethylphenyl)-1-ethanone oxime

4-ethyl-2-(1-hydroxy-1-methyl-but-3-enyl)-phenol