Lodoxamide ethyl

Base Information

Chemical Name:Lodoxamide ethyl
CAS No.:53882-13-6
Molecular Formula:C15H14 Cl N3 O6
Molecular Weight:367.746
Hs Code.:2926909090
UNII:TQY1B8145B
DSSTox Substance ID:DTXSID90202137
Nikkaji Number:J10.846D
Wikidata:Q27290175
NCI Thesaurus Code:C170124
ChEMBL ID:CHEMBL2107161
Mol file:53882-13-6.mol

Synonyms:diethyl N,N'-(2-chloro-5-cyano-m-phenylene)dioxamate;lodoxamide;lodoxamide ethyl;U-42,718

Suppliers and Price of Lodoxamide ethyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
LodoxamideDiethylEster
100mg
$ 250.00

American Custom Chemicals Corporation
ETHYL (2-CHLORO-5-CYANO-3-([ETHOXY(OXO)ACETYL]AMINO)ANILINO)(OXO)ACETATE 95.00%
5MG
$ 501.18

Total 5 raw suppliers

Chemical Property of Lodoxamide ethyl

Chemical Property:

Melting Point:177-179°
Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：134.59000
Density:1.43g/cm³
LogP:1.36088
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:367.0571129
Heavy Atom Count:25
Complexity:545

Purity/Quality:

95% ^*data from raw suppliers

LodoxamideDiethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(=O)NC1=CC(=CC(=C1Cl)NC(=O)C(=O)OCC)C#N
Uses Anti-allergic; anti-asthmatic. Lodoxamide Diethyl Ester is an intermediate in the synthesis of Lodoxamide (L469365), an antiallergic drug that acts as a mast cell stabilizer.

Technology Process of Lodoxamide ethyl

There total 3 articles about Lodoxamide ethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34207-46-0
2-chloro-5-cyano-1,3-phenylenediamine

: 4755-77-5
Ethyl oxalyl chloride

: 53882-13-6
diethyl N,N'-(2-chloro-5-cyano-m-phenylene)dioxamate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00207a016

Reference yield:

: 1930-72-9
4-chloro-3,5-dinitrobenzonitrile

: 53882-13-6
diethyl N,N'-(2-chloro-5-cyano-m-phenylene)dioxamate

Guidance literature:: Multi-step reaction with 2 steps

1: SnCl₂, aq. HCl

2: Et₃N / dimethylformamide

With hydrogenchloride; triethylamine; tin(ll) chloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00207a016