1H-Indole-1-carboxylic acid, 5-[(3S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[(phenylmethoxy)carb onyl]amino]butyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Indole-1-carboxylic acid, 5-[(3S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[(phenylmethoxy)carb onyl]amino]butyl]-, 1,1-dimethylethyl ester
CAS No.:672964-43-1
Molecular Formula:C31H44N2O5Si
Molecular Weight:552.786
Hs Code.:

1H-Indole-1-carboxylic acid,
5-[(3S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[(phenylmethoxy)carb
onyl]amino]butyl]-, 1,1-dimethylethyl ester

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Chemical Property of 1H-Indole-1-carboxylic acid, 5-[(3S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[(phenylmethoxy)carb onyl]amino]butyl]-, 1,1-dimethylethyl ester

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Technology Process of 1H-Indole-1-carboxylic acid, 5-[(3S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[(phenylmethoxy)carb onyl]amino]butyl]-, 1,1-dimethylethyl ester

There total 4 articles about 1H-Indole-1-carboxylic acid, 5-[(3S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[(phenylmethoxy)carb onyl]amino]butyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 182344-70-3
5-bromo-indole-1-carboxylic acid tert-butyl ester

: [3-(9-bora-bicyclo[3.3.1]non-9-yl)-1-(tert-butyl-dimethyl-silanyloxymethyl)-propyl]-carbamic acid benzyl ester

: 672964-43-1
5-[3-benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyl]-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: With cesium fluoride; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In 1,4-dioxane; at 80 ℃;
DOI:10.1002/chem.200305421

Reference yield:

: 121421-45-2
N^α-benzyloxycarbonyl-L-methioninol

: 672964-43-1
5-[3-benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyl]-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole / CH₂Cl₂ / 0 - 20 °C

2: 38.04 g / aq. NaIO₄ / methanol / 2 h / 20 °C

3: 88 percent / CaCO₃ / 1,2-dichloro-benzene / 4 h / 180 °C

4: dioxane / 0.33 h / 80 °C

5: CsF / [Pd(dppf)Cl₂] / dioxane / 80 °C

With 1H-imidazole; sodium periodate; cesium fluoride; calcium carbonate; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-benzene; 5: Suzuki reaction;
DOI:10.1002/chem.200305421

Reference yield:

: [1-(tert-butyl-dimethyl-silanyloxymethyl)-3-methylsulfanyl-propyl]-carbamic acid benzyl ester

: 672964-43-1
5-[3-benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyl]-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 38.04 g / aq. NaIO₄ / methanol / 2 h / 20 °C

2: 88 percent / CaCO₃ / 1,2-dichloro-benzene / 4 h / 180 °C

3: dioxane / 0.33 h / 80 °C

4: CsF / [Pd(dppf)Cl₂] / dioxane / 80 °C

With sodium periodate; cesium fluoride; calcium carbonate; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In 1,4-dioxane; methanol; 1,2-dichloro-benzene; 4: Suzuki reaction;
DOI:10.1002/chem.200305421