MPEG3-CH2CH2COOH

Base Information

• Chemical Name: MPEG3-CH2CH2COOH
• CAS No.: 67319-28-2
• Molecular Formula: C10H20O6
• Molecular Weight: 236.26200
• Mol file: 67319-28-2.mol

Synonyms:2,5,8,11-Tetraoxatetradecan-14-oic acid (9CI);

Chemical Property of MPEG3-CH2CH2COOH

Chemical Property:

• Boiling Point: 352.3±32.0 °C(Predicted)
• PKA: 4.28±0.10(Predicted)
• PSA: 74.22000
• Density: 1.105±0.06 g/cm3(Predicted)
• LogP: 0.15730
• Storage Temp.: 2-8°C
• Solubility.: Soluble in Water

Purity/Quality:

97% ^*data from raw suppliers

4,7,10,13-Tetraoxatetradecanoicacid min.95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: m-PEG4-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Technology Process of MPEG3-CH2CH2COOH

There total 7 articles about MPEG3-CH2CH2COOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 2,5,8,11-tetraoxatetradecan-14-oate (883554-11-8) → 3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-propionic acid (125220-94-2,67319-28-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield: 85.0%

triethylene glucol monomethyl ether (112-35-6,95507-80-5) + tert-Butyl acrylate (1663-39-4,25232-27-3) → 3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-propionic acid (125220-94-2,67319-28-2)

Guidance literature:

triethylene glucol monomethyl ether; tert-Butyl acrylate; With sodium; In tetrahydrofuran; at 20 ℃; for 13.5h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;

Reference yield: 54.0%

→ 3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-propionic acid (125220-94-2,67319-28-2)

Guidance literature:

With sodium; In tetrahydrofuran; at 0 - 20 ℃; for 24h; Inert atmosphere;

With water; sodium hydroxide; for 5h;

upstream raw materials:

tert-butyl 2,5,8,11-tetraoxatetradecan-14-oate

triethylene glucol monomethyl ether

acrylic acid methyl ester

tert-Butyl acrylate