m-PEG4-t-butyl ester

Base Information

• Chemical Name: m-PEG4-t-butyl ester
• CAS No.: 883554-11-8
• Molecular Formula: C14H28O6
• Molecular Weight: 292.37
• Mol file: 883554-11-8.mol

Synonyms:m-PEG4-t-butyl ester

Chemical Property of m-PEG4-t-butyl ester

Chemical Property:

• PSA: 63.22000
• LogP: 1.41440

Purity/Quality:

98%,99%, ^*data from raw suppliers

m-PEG4-t-butylester 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: m-PEG4-t-butyl ester is a PEG linker containing a t-butyl ester. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.

Technology Process of m-PEG4-t-butyl ester

There total 1 articles about m-PEG4-t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.3%

triethylene glucol monomethyl ether (112-35-6,95507-80-5) + tert-Butyl acrylate (1663-39-4,25232-27-3) → tert-butyl 2,5,8,11-tetraoxatetradecan-14-oate (883554-11-8)

Guidance literature:

With sodium methylate; at 20 ℃;

Reference yield: 100.0%

tert-butyl 2,5,8,11-tetraoxatetradecan-14-oate (883554-11-8) → 3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-propionic acid (125220-94-2,67319-28-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

tert-butyl 2,5,8,11-tetraoxatetradecan-14-oate (883554-11-8) → triethylene glycol monomethyl ether propionic acid-N-succinimidyl ester (622405-78-1)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid; water / 2 h / 80 °C

2: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0 - 45 °C

3: triethylamine / dichloromethane / 0 - 20 °C

With thionyl chloride; water; toluene-4-sulfonic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

triethylene glucol monomethyl ether

tert-Butyl acrylate

Downstream raw materials:

3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-propionic acid

triethylene glycol monomethyl ether propionic acid-N-succinimidyl ester

Refernces

• 1、 -. "PEPTIDIC LINKERS AND CRYPTOPHYCIN CONJUGATES, USEFUL IN THERAPY, AND THEIR PREPARATION". Page/Page column 165; 166. . Retrieved 2018/12/02.
• 2、 -. "Protease Stabilized, Pegylated Insulin Analogues". . . Retrieved 2010/09/05.