(1R,2R)-[N,N′-Bis(2′,3′-dihydroxybenzylidene)]-1,2-diaMinocyclohexane

Base Information

• Chemical Name: (1R,2R)-[N,N′-Bis(2′,3′-dihydroxybenzylidene)]-1,2-diaMinocyclohexane
• CAS No.: 674285-08-6
• Molecular Formula: C20H22N2O4
• Molecular Weight: 354.40000
• Mol file: 674285-08-6.mol

Synonyms:(1R,2R)-[N,N'-Bis(2',3'-dihydroxybenzylidene)]-1,2-diaminocyclohexane;

Chemical Property of (1R,2R)-[N,N′-Bis(2′,3′-dihydroxybenzylidene)]-1,2-diaMinocyclohexane

Chemical Property:

• Melting Point: 94-116°C
• Boiling Point: 603.1±55.0 °C(Predicted)
• PKA: 11.04±0.10(Predicted)
• Flash Point: >110℃
• PSA: 98.66000
• Density: 1.32±0.1 g/cm3(Predicted)
• LogP: 3.18800

Purity/Quality:

98%,99%, ^*data from raw suppliers

(1R,2R)-[N,N′-Bis(2′,3′-dihydroxybenzylidene)]-1,2-diaminocyclohexane 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,2R)-[N,N′-Bis(2′,3′-dihydroxybenzylidene)]-1,2-diaMinocyclohexane

There total 2 articles about (1R,2R)-[N,N′-Bis(2′,3′-dihydroxybenzylidene)]-1,2-diaMinocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,3-dihydroxybenzaldehyde (24677-78-9) + trans-1,2-Diaminocyclohexane (1121-22-8,1436-59-5,20439-47-8,21436-03-3,41013-43-8,694-83-7) → C20H22N2O4 (674285-08-6)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Heating;

DOI:10.1039/b311483j

Reference yield: 64.0%

2,3-dihydroxybenzaldehyde (24677-78-9) + (1R,2R)-1,2-diaminocyclohexane monohydrochloride (191480-63-4) → (1R,2R)-[N,N'-bis(2',3'-dihydroxybenzylidene)]-1,2-diaminocyclohexane (674285-08-6)

Guidance literature:

With sodium methylate; In methanol; for 2h; Heating;

DOI:10.1016/j.tet.2004.05.023

Reference yield:

N,N'-(1R,2R)-(-)-1,2-cyclohexylenebis(3-hydroxysalicylideneamine) (674285-08-6) + para-tert-butylphenol (98-54-4) + copper diacetate (142-71-2) + samarium(III) isopropoxide → [Cu(C6H10(NCHC6H3(O)2)2)Sm(O(4-tBuC6H4))]

Guidance literature:

DOI:10.1021/ja0701560 DOI:10.1002/anie.200705617

upstream raw materials:

2,3-dihydroxybenzaldehyde

trans-1,2-Diaminocyclohexane

(1R,2R)-1,2-diaminocyclohexane monohydrochloride