5-Chloro-3-(4-hydroxyphenyl)-2,1-benzisoxazole

Base Information

• Chemical Name: 5-Chloro-3-(4-hydroxyphenyl)-2,1-benzisoxazole
• CAS No.: 67445-85-6
• Molecular Formula: C13H8ClNO2
• Molecular Weight: 245.665
• Mol file: 67445-85-6.mol

Synonyms:5-Chlor-3-p-hydroxy-phenyl-anthranil;5-chloro-3-(4-hydroxyphenyl)-2,1-benzisoxazole;4-(5-Chlor-benz[c]isoxazol-3-yl)-phenol;3-[4'-Hydroxy-phenyl]-5-chlor-anthranil;4-(5-chloro-benz[c]isoxazol-3-yl)-phenol;

Chemical Property of 5-Chloro-3-(4-hydroxyphenyl)-2,1-benzisoxazole

Chemical Property:

• Boiling Point: 442.9±30.0 °C(Predicted)
• PKA: 8.77±0.15(Predicted)
• PSA: 46.26000
• Density: 1.401±0.06 g/cm3(Predicted)
• LogP: 3.85380

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-3-(4-hydroxyphenyl)-2,1-benzisoxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Chloro-3-(4-hydroxyphenyl)-2,1-benzisoxazole

There total 3 articles about 5-Chloro-3-(4-hydroxyphenyl)-2,1-benzisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitro-benzaldehyde (552-89-6) + phenol (108-95-2,27073-41-2) → 4-(5-chloro-benzo[c]isoxazol-3-yl)-phenol (67445-85-6)

Guidance literature:

With hydrogenchloride; In diethyl ether;

DOI:10.1039/jr9620003092

Reference yield:

5-chloro-2-nitrobenzaldehyde (6628-86-0) + phenol (108-95-2,27073-41-2) → 4-(5-chloro-benzo[c]isoxazol-3-yl)-phenol (67445-85-6)

Guidance literature:

With hydrogen bromide; In diethyl ether;

DOI:10.1039/jr9620003092

Reference yield:

2-nitro-benzaldehyde (552-89-6) → 4-(5-chloro-benzo[c]isoxazol-3-yl)-phenol (67445-85-6)

Guidance literature:

With acetic acid; trichlorophosphate; phenol;

upstream raw materials:

2-nitro-benzaldehyde

phenol

5-chloro-2-nitrobenzaldehyde

Downstream raw materials:

2-amino-5-chloro-4'-hydroxy-benzophenone