Technology Process of 2(1H)-Quinolinone,
5-[2-[(1,1-dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-8-hydroxy-
There total 16 articles about 2(1H)-Quinolinone,
5-[2-[(1,1-dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-8-hydroxy- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen; ammonium formate;
palladium on activated charcoal;
In
methanol;
at 20 - 50 ℃;
for 1.25h;
DOI:10.1021/jm00392a006
- Guidance literature:
-
Multi-step reaction with 2 steps
1: butan-1-ol / 4 h / Heating
2: ammonium formate; 10 percent Pd/C / methanol / Heating
With
palladium on activated charcoal; ammonium formate;
In
methanol; butan-1-ol;
DOI:10.1007/PL00005339
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) NaH / 1.) DMF, 45 min, 2.) DMF, 4 h
2: m-chloroperbenzoic acid / CH2Cl2 / 4 h / Ambient temperature
3: 55 percent / pyridinium chlorochromate / CH2Cl2 / 1 h
4: 1.98 g / Ac2O / 2.5 h / 50 °C
5: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min
6: 40 mg / propan-2-ol / 24 h / Heating
7: H2, ammonium formate / 10percent Pd/C / methanol / 1.25 h / 20 - 50 °C
With
hydrogen; ammonium formate; acetic anhydride; sodium hydride; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate;
palladium on activated charcoal;
In
methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm00392a006
